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Bone Response to Free-Form Fabricated Hydroxyapatite and Zirconia Scaffolds: A Transmission Electron Microscopy Study in the Human Maxilla.

Artikel i vetenskaplig tidskrift
Författare Kathryn Grandfield
Anders Palmquist
Fredric Ericson
Johan Malmström
Lena Emanuelsson
Christer Slotte
Erik Adolfsson
Gianluigi A Botton
Peter Thomsen
Håkan Engqvist
Publicerad i Clinical implant dentistry and related research
Volym 14
Nummer/häfte 3
Sidor 461-469
ISSN 1708-8208
Publiceringsår 2012
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Sidor 461-469
Språk en
Länkar dx.doi.org/10.1111/j.1708-8208.2009...
Ämnesord osseointegration, hydroxyapatite, zirconia, scaffolds, free form fabrication, FIB, TEM
Ämneskategorier Biomaterialvetenskap

Sammanfattning

ABSTRACT Background: Understanding the interfacial reactions to synthetic bone regenerative scaffolds in vivo is fundamental for improving osseointegration and osteogenesis. Using transmission electron microscopy, it is possible to study the biological response of hydroxyapatite (HA) and zirconia (ZrO(2)) scaffolds at the nanometer scale. Purpose: In this study, the bone-bonding abilities of HA and ZrO(2) scaffolds produced by free-form fabrication were evaluated in the human maxilla at 3 months and 7 months. Materials and Methods: HA and ZrO(2) scaffolds (ø: 3 mm) were implanted in the human maxilla, removed with surrounding bone, embedded in resin, and sectioned. A novel focused ion beam (FIB) sample preparation technique enabled the production of thin lamellae for study by scanning transmission electron microscopy. Results: Interface regions were investigated using high-angle annular dark-field imaging and energy-dispersive X-ray spectroscopy analysis. Interfacial apatite layers of 80 nm and 50 nm thickness were noted in the 3- and 7-month HA samples, respectively, and bone growth was discovered in micropores up to 10 microm into the samples. Conclusions: The absence of an interfacial layer in the ZrO(2) samples suggest the formation of a direct contact with bone, while HA, which bonds through an apatite layer, shows indications of resorption with increasing implantation time. This study demonstrates the potential of HA and ZrO(2) scaffolds for use as bone regenerative materials.

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