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Overweight in midlife is related to lower cognitive function 30 years later: a prospective study with longitudinal assessments.

Artikel i vetenskaplig tidskrift
Författare Linda Hassing
Anna K Dahl
Nancy L Pedersen
Boo Johansson
Publicerad i Dementia and geriatric cognitive disorders
Volym 29
Nummer/häfte 6
Sidor 543-52
ISSN 1421-9824
Publiceringsår 2010
Publicerad vid Psykologiska institutionen
Sidor 543-52
Språk en
Länkar dx.doi.org/10.1159/000314874
Ämneskategorier Folkhälsomedicinska forskningsområden

Sammanfattning

AIM: To examine if the body mass index (BMI) in midlife is related to cognitive function 30 years later in a dementia-free sample. METHODS: BMI was reported in 1963 at age 50-60 years, and cognitive abilities were examined 30 years later in a longitudinal design with 5 measurement occasions at 2-year intervals (n = 417). The cognitive abilities examined included tests of long-term memory, short-term memory, speed, verbal and spatial ability. RESULTS: Multilevel modeling adjusting for demographic and lifestyle factors, and relevant diseases showed that a higher BMI in midlife predicted lower test performance 30 years later. Significant associations between BMI and level of performance were found in all cognitive abilities; however, a higher midlife BMI was not associated with steeper cognitive decline. CONCLUSION: Our results indicate that midlife overweight is related to lower overall cognitive function in old age. The fact that BMI-related effects were noted in mean-level cognitive performance, whereas only one ability showed differences in slopes, suggests that the negative effect of overweight has an onset before the entry into very old age.

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