Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Evidence for geographical… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Evidence for geographical and racial variation in serum sex steroid levels in older men.

Artikel i vetenskaplig tidskrift
Författare Eric S Orwoll
Carrie M Nielson
Fernand Labrie
Elizabeth Barrett-Connor
Jane A Cauley
Steven R Cummings
Kristine Ensrud
Magnus K Karlsson
Edith Lau
P C Leung
Östen Lunggren
Dan Mellström
Alan L Patrick
Marcia L Stefanick
Kozo Nakamura
Noriko Yoshimura
Joseph Zmuda
Liesbeth Vandenput
Claes Ohlsson
Publicerad i The journal of clinical endocrinology and metabolism
Volym 95
Nummer/häfte 10
Sidor E151-60
ISSN 1945-7197
Publiceringsår 2010
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Centre for Bone and Arthritis Research
Institutionen för medicin, avdelningen för invärtesmedicin
Sidor E151-60
Språk en
Länkar dx.doi.org/10.1210/jc.2009-2435
Ämneskategorier Endokrinologi

Sammanfattning

Background: Despite considerable racial and geographical differences in human phenotypes and in the incidence of diseases that may be associated with sex steroid action, there are few data concerning variation in sex steroid levels among populations. We designed an international study to determine the degree to which geography and race influence sex steroid levels in older men. Methods: Using mass spectrometry, concentrations of serum androgens, estrogens, and sex steroid precursors/metabolites were measured in 5003 older men from five countries. SHBG levels were assessed using radioimmunoassay. Results: There was substantial geographical variation in the levels of sex steroids, precursors, and metabolites, as well as SHBG. For instance, Asian men in Hong Kong and Japan, but not in the United States, had levels of total testosterone approximately 20% higher than in other groups. Even greater variation was present in levels of estradiol, SHBG, and dihydrotestosterone. Group differences in body mass index did not explain most geographical differences. In addition, body mass index-independent racial differences were present; Black men had higher levels of estrogens (estradiol, estrone), and Asian men had lower levels of glucuronidated androgen metabolites. Conclusions: On a global scale, there are important geographical and racial differences in the concentrations of serum sex steroids and SHBG in older men.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?