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Impact of pulse oximetry screening on the detection of duct dependent congenital heart disease: a Swedish prospective screening study in 39,821 newborns.

Artikel i vetenskaplig tidskrift
Författare Anne de-Wahl Granelli
Margareta Wennergren
Kenneth Sandberg
Mats Mellander
Carina Bejlum
Leif Inganäs
Monica Eriksson
Niklas Segerdahl
Annelie Agren
Britt-Marie Ekman-Joelsson
Jan Sunnegårdh
Mario Verdicchio
Ingegerd Östman-Smith
Publicerad i BMJ (Clinical research ed.)
Volym 338
Sidor a3037
ISSN 1468-5833
Publiceringsår 2009
Publicerad vid Institutionen för kliniska vetenskaper
Sidor a3037
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord False Positive Reactions, Heart Defects, Congenital, diagnosis, epidemiology, Humans, Infant, Newborn, Neonatal Screening, methods, Oximetry, methods, Physical Examination, Pilot Projects, Prospective Studies, Sweden, epidemiology
Ämneskategorier Fysiologi, Barnkardiologi, Barn

Sammanfattning

OBJECTIVE: To evaluate the use of pulse oximetry to screen for early detection of life threatening congenital heart disease. DESIGN: Prospective screening study with a new generation pulse oximeter before discharge from well baby nurseries in West Götaland. Cohort study comparing the detection rate of duct dependent circulation in West Götaland with that in other regions not using pulse oximetry screening. Deaths at home with undetected duct dependent circulation were included. SETTING: All 5 maternity units in West Götaland and the supraregional referral centre for neonatal cardiac surgery. PARTICIPANTS: 39,821 screened babies born between 1 July 2004 and 31 March 2007. Total duct dependent circulation cohorts: West Götaland n=60, other referring regions n=100. MAIN OUTCOME MEASURES: Sensitivity, specificity, positive and negative predictive values, and likelihood ratio for pulse oximetry screening and for neonatal physical examination alone. RESULTS: In West Götaland 29 babies in well baby nurseries had duct dependent circulation undetected before neonatal discharge examination. In 13 cases, pulse oximetry showed oxygen saturations

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