Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Clozapine: agonistic and … - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Clozapine: agonistic and antagonistic salivary secretory actions.

Artikel i vetenskaplig tidskrift
Författare Jörgen Ekström
Tania Godoy
A Riva
Publicerad i Journal of dental research
Volym 89
Nummer/häfte 3
Sidor 276-80
ISSN 1544-0591
Publiceringsår 2010
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 276-80
Språk en
Länkar dx.doi.org/10.1177/0022034509356055
Ämnesord Animals, Antipsychotic Agents, pharmacology, Autonomic Denervation, Cholinergic Agents, pharmacology, Clozapine, pharmacology, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Parotid Gland, drug effects, innervation, secretion, Rats, Rats, Sprague-Dawley, Receptors, Adrenergic, beta, drug effects, Receptors, Muscarinic, drug effects, Saliva, secretion, Salivation, drug effects, Sialorrhea, chemically induced, Submandibular Gland, drug effects, innervation, secretion
Ämneskategorier Fysiologi, Farmakologisk forskning

Sammanfattning

Individuals receiving clozapine treatment for schizophrenia complain of drooling. Reports on salivary flow measurements are contradictory in humans and lacking in animals. Clozapine has affinity for several different receptor types and may, hypothetically, both stimulate and inhibit salivary secretion. In rats, intravenous clozapine evoked a long-lasting secretion, being more prominent from submandibular than from parotid glands. Chronic denervation enhanced the responses. Clozapine acted on muscarinic (M1-) receptors of acinar cells, independent of central nervous mechanisms, pre-synaptic intraglandular events, or circulating catecholamines. A fraction of the methacholine- and parasympathetic-nerve-evoked secretion was abolished by clozapine at doses below those evoking secretion. Sympathetic-nerve-evoked secretion was partially reduced by clozapine, due to antagonistic action on alpha-adrenoceptors; the beta-adrenoceptor-mediated response persisted. Subsecretory doses of clozapine enhanced secretion induced by the beta-adrenoceptor agonist isoprenaline. The overall actions of clozapine suggest that, in clozapine-treated humans, salivation is increased during sleep and at rest, but is decreased during meals.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?