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Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers.

Artikel i vetenskaplig tidskrift
Författare Magnus Lindh
Charles Hannoun
Amar P Dhillon
Gunnar Norkrans
Peter Horal
Publicerad i The Journal of infectious diseases
Volym 179
Nummer/häfte 4
Sidor 775-82
ISSN 0022-1899
Publiceringsår 1999
Publicerad vid Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar
Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi
Sidor 775-82
Språk en
Länkar dx.doi.org/10.1086/314688
Ämnesord Adolescent, Adult, Carrier State, virology, Female, Genotype, Hepatitis B, pathology, virology, Hepatitis B e Antigens, analysis, Hepatitis B virus, classification, genetics, physiology, Humans, Liver, pathology, Male, Middle Aged, Mutation, Promoter Regions, Genetic, Virus Replication
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

Virus load and liver damage, as measured by quantitative polymerase chain reaction and histology activity index, were related to genotype and core promoter mutations in 43 chronic hepatitis B virus (HBV) carriers of East Asian origin. T-1762 mutants were more frequent in genotype C strains and were associated with more inflammation (P=.0036) and fibrosis (P=.0088) of the liver but not with hepatitis B e antigen (HBeAg) status or virus load. Conversely, precore mutations were associated with less liver inflammation (P=. 08), which was linked to HBeAg negativity and lower viral replication. Carriers with genotype C were more often HBeAg positive (P=.03) with precore wild type strains and more-severe liver inflammation (P=.009) than were those with genotype B. These findings suggest that pathogenic differences between genotypes may exist and that the T-1762 mutation may be useful as a marker for progressive liver damage but seem to contradict that down-regulation of HBeAg production is the major effect of this mutation.

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