Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Overexpression of Foxf2 i… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo.

Artikel i vetenskaplig tidskrift
Författare Rickard Westergren
Daniel Nilsson
Mikael Heglind
Zahra Arani
Mats Grände
Anna Cederberg
Bo Ahrén
Sven Enerbäck
Publicerad i American journal of physiology. Endocrinology and metabolism
Volym 298
Nummer/häfte 3
Sidor E548-54
ISSN 1522-1555
Publiceringsår 2010
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik
Sidor E548-54
Språk en
Länkar dx.doi.org/10.1152/ajpendo.00395.20...
Ämnesord 3T3 Cells, Adipocytes, Adipose Tissue, metabolism, Animals, Down-Regulation, Forkhead Transcription Factors, metabolism, Gene Expression, Glucose, metabolism, Homeostasis, genetics, Humans, Insulin Receptor Substrate Proteins, metabolism, Mice, Mice, Inbred C57BL
Ämneskategorier Cell- och molekylärbiologi

Sammanfattning

Many members of the forkhead genes family of transcription factors have been implicated as important regulators of metabolism, in particular, glucose homeostasis, e.g., Foxo1, Foxa3, and Foxc2. The purpose of this study was to exploit the possibility that yet unknown members of this gene family play a role in regulating glucose tolerance in adipocytes. We identified Foxf2 in a screen for adipose-expressed forkhead genes. In vivo overexpression of Foxf2 in an adipose tissue-restricted fashion demonstrated that such mice display a significantly induced insulin secretion in response to an intravenous glucose load compared with wild-type littermates. In response to increased Foxf2 expression, insulin receptor substrate 1 (IRS1) mRNA and protein levels are significantly downregulated in adipocytes; however, the ratio of serine vs. tyrosine phosphorylation of IRS1 seems to remain unaffected. Furthermore, adipocytes overexpressing Foxf2 have a significantly lower insulin-mediated glucose uptake compared with wild-type adipocytes. These findings argue that Foxf2 is a previously unrecognized regulator of cellular and systemic whole body glucose tolerance, at least in part, due to lower levels of IRS1. Foxf2 and its downstream target genes can provide new insights with regard to identification of novel therapeutic targets.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?