Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Anterior to posterior hip… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Anterior to posterior hippocampal MRS metabolite difference is mainly a partial volume effect.

Artikel i vetenskaplig tidskrift
Författare Göran Starck
Barbro Vikhoff-Baaz
Maria Ljungberg
Kristina Malmgren
Eva Forssell-Aronsson
Lars Jönsson
Sven Ekholm
Publicerad i Acta radiologica
Volym 51
Nummer/häfte 3
Sidor 351-359
ISSN 1600-0455
Publiceringsår 2010
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för radiofysik
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Sidor 351-359
Språk en
Länkar dx.doi.org/10.3109/0284185090354040...
Ämnesord Adult, Aspartic Acid, analogs & derivatives, metabolism, Choline, metabolism, Creatine, metabolism, Female, Hippocampus, metabolism, Humans, Imaging, Three-Dimensional, Magnetic Resonance Spectroscopy, methods, Male, Middle Aged, Reference Values, Reproducibility of Results, Signal Processing, Computer-Assisted, Temporal Lobe, metabolism, Young Adult
Ämneskategorier Radiofysik

Sammanfattning

BACKGROUND: The concentration of N-acetylaspartate (NAA) in hippocampus, as measured with magnetic resonance spectroscopy (MRS), and the ratio of NAA/(choline (Cho) + creatine (Cr)) are valuable tools in the lateralization of temporal lobe epilepsy (TLE). MRS of hippocampus is also increasingly used to study certain psychiatric and degenerative diseases. However, the reliability of such measurements of hippocampus has been questioned. PURPOSE: To re-evaluate MRS imaging data from prior control subjects with regard to variation of metabolite concentrations in hippocampus from anterior to posterior and the partial volume (R)contribution to the measurements from adjacent tissue. MATERIAL AND METHODS: Twelve healthy subjects, mean age 33 years, were studied with MRS imaging. The measurement volume was angled along the temporal horns and metabolite concentration images were reconstructed at the MR system. Regions of interest (ROIs) in the anterior, medial, and posterior parts of both hippocampi were evaluated. Signal normalization to the total MRS signal from all ROIs permitted pooling of individual data with different and unknown signal scaling. One subject was re-examined with a high resolution three-dimensional (3D) volume of the brain for evaluation of partial volumes in the MRS examination. RESULTS: Overall, there were significantly lower concentrations of NAA in the anterior parts, and of (Cho+Cr) in the posterior parts, while the NAA/(Cho+Cr) ratio in the posterior parts of the mesial temporal lobes was significantly higher. Hippocampus accounted for one-half, one-third, and one-quarter of the anterior, middle, and posterior ROIs, respectively. The NAA/(Cho+Cr) ratio thus showed a reverse relationship to the relative volume of hippocampal tissue within the ROI. CONCLUSION: Metabolite concentrations in the mesial temporal lobe obtained with MRS imaging represent the mean value of hippocampus and a considerable amount of adjacent tissue. To assess the hippocampus alone, an actual voxel well below 1 cm(3) and a sub-centimeter slice thickness are required.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?