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Glycosphingolipid receptors for Pseudomonas aeruginosa.

Artikel i vetenskaplig tidskrift
Författare N Baker
Gunnar C. Hansson
Hakon Leffler
Gerdt C. Riise
Catharina Svanborg-Edén
Publicerad i Infection and immunity
Volym 58
Nummer/häfte 7
Sidor 2361-6
ISSN 0019-9567
Publiceringsår 1990
Publicerad vid Medicinska institutionen
Sidor 2361-6
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Antigens, CD, Bacterial Adhesion, physiology, Carbohydrate Sequence, Epithelium, microbiology, Glycosphingolipids, metabolism, Humans, Lactosylceramides, Molecular Sequence Data, Mouth, microbiology, N-Acetylneuraminic Acid, Pseudomonas aeruginosa, metabolism, Sialic Acids, metabolism
Ämneskategorier Mikrobiologi inom det medicinska området, Infektionsmedicin

Sammanfattning

The binding of Pseudomonas aeruginosa to glycosphingolipids and to buccal and bronchial epithelial cells was analyzed. Three independently expressed specificities were found by bacterial binding to glycosphingolipids separated by thin-layer chromatography. All strains bound gangliotria- and gangliotetrasylceramide. All but one of the strains bound sialic acid-containing glycosphingolipids and lactosylceramide. The latter two specificities could be separated in that the lactosylceramide binding was retained and the sialic acid binding was suppressed when bovine serum albumin was used as a blocking agent in the thin-layer chromatography assay. The attachment to buccal epithelial cells, like the binding to sialylated compounds and lactosylceramide, was abolished by Formalin treatment of the bacteria, suggesting the importance of these specificities for cell adherence. In contrast, the binding to gangliotria- and gangliotetraosylceramide was retained by nonattaching Formalin-treated bacteria.

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