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Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss.

Artikel i vetenskaplig tidskrift
Författare Atsuhito Saiki
Maja Olsson
Margareta Jernås
Anders Gummesson
Philip G McTernan
Johanna Andersson
Peter Jacobson
Kajsa Sjöholm
Bob Olsson
Shigeo Yamamura
Andrew Walley
Philippe Froguel
Björn Carlsson
Lars Sjöström
Per-Arne Svensson
Lena M S Carlsson
Publicerad i The Journal of clinical endocrinology and metabolism
Volym 94
Nummer/häfte 10
Sidor 3987-94
ISSN 1945-7197
Publiceringsår 2009
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 3987-94
Språk en
Länkar dx.doi.org/10.1210/jc.2009-0292
Ämnesord Adipocytes, metabolism, Adipose Tissue, metabolism, Adult, Aged, Body Mass Index, Diet, Reducing, Down-Regulation, Female, Humans, Male, Membrane Proteins, genetics, metabolism, Middle Aged, Obesity, diet therapy, metabolism, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Sweden, Weight Loss
Ämneskategorier Molekylär medicin (genetik och patologi)

Sammanfattning

CONTEXT: Tenomodulin (TNMD), a putative angiogenesis inhibitor, is expressed in hypovascular connective tissues. Global gene expression scans show that the TNMD gene also is expressed in human adipose tissue and that its expression is regulated in response to weight reduction; however, more detailed information is lacking. OBJECTIVE: The aim of this study was to investigate TNMD tissue distribution and TNMD gene expression in human adipose tissue in relation to obesity and metabolic disease. DESIGN, PATIENTS, AND INTERVENTIONS: TNMD gene expression, tissue distribution, and TNMD gene expression in adipose tissue from different depots, from lean and obese subjects, and during diet-induced weight reduction were analyzed by DNA microarray and real-time PCR. MAIN OUTCOME MEASURE: We primarily measured TNMD gene expression. RESULTS: The TNMD gene was predominantly expressed in sc adipose tissue. TNMD gene expression was higher in sc than omental adipose tissue both in lean (P = 0.002) and obese subjects (P = 0.014). In both women and men, TNMD gene expression was significantly higher in the obese subjects compared to the lean subjects (P = 1.1 x 10(-26) and P = 0.010, respectively). In a multiple linear regression analysis, BMI was a significant independent predictor of TNMD gene expression. TNMD gene expression was down-regulated during diet-induced weight loss, with a 65% decrease after 18 wk of diet (P < 0.0001). CONCLUSIONS: We conclude that human adipose tissue TNMD gene expression is highly affected by obesity, adipose tissue location, and weight loss, indicating that TNMD may play a role in adipose tissue function.

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