Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

CHARACTERIZATION OF THE G… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

CHARACTERIZATION OF THE GROWTH HORMONE – INSULIN-LIKE GROWTH FACTOR I SYSTEM DURING ATLANTIC HALIBUT METAMORPHOSIS

Konferensbidrag (offentliggjort, men ej förlagsutgivet)
Författare Jon Hildahl
Ingibjörg Einarsdottir
M Galay-Burgos
GE Sweeney
DM Power
Björn Thrandur Björnsson
Publicerad i 7th International Congress on the Biology of Fish, Book of Abstracts
Publiceringsår 2006
Publicerad vid Zoologiska institutionen
Språk en
Ämneskategorier Biologiska vetenskaper

Sammanfattning

The GH-IGF-I system is critical for proper growth and development in fish and thus is likely to play a role in the control of flatfish metamorphosis.. In order to characterize the role of GH and IGF-I in Atlantic halibut development, hormonal content (GH and IGF-I RIA) and receptor gene expression (GHR and IGF-IR QPCR) was assessed during normal and abnormal metamorphosis GH larval head content increases throughout normal metamorphosis in parallel with larval weight. The full-length GH receptor (hhGHRfl) mRNA and IGF-I protein levels change in parallel and in a stage-specific manner, with an increase at the onset of metamorphosis followed by down-regulation. Two isoforms of the IGF-I receptor are regulated differently; isoform one (hhIGF-IR1) mRNA increases from pre-metamorphosis to the post-metamorphic juvenile stage, while isoform 2 (hhIGF-IR2) mRNA is highest at early pre-metamorphosis and decreases prior to the onset of metamorphosis. In larvae experiencing arrested development, mRNA levels for hhGHRfl and hhIGF-IR1 and IGF-I larval content are depressed relative to normal individuals, whereas GH content, hhIGF-IR2 mRNA levels and weight are not changed. Increased hhGHRfl mRNA and IGF-I protein levels at the onset of metamorphosis suggest that tissue sensitivity to GH increases during metamorphosis while tissue sensitivity to IGF-I does not change. The data provide new evidence suggesting that GHR and IGF-IR levels may be of critical importance for metamorphic success in Atlantic halibut. Funded by the EU and FORMAS.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?