Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

MTERF3 is a negative regu… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

MTERF3 is a negative regulator of mammalian mtDNA transcription.

Artikel i vetenskaplig tidskrift
Författare Chan Bae Park
Jorge Asin-Cayuela
Yolanda Cámara
Yonghong Shi
Mina Pellegrini
Martina Gaspari
Rolf Wibom
Kjell Hultenby
Hediye Erdjument-Bromage
Paul Tempst
Maria Falkenberg
Claes M Gustafsson
Nils-Göran Larsson
Publicerad i Cell
Volym 130
Nummer/häfte 2
Sidor 273-85
ISSN 0092-8674
Publiceringsår 2007
Publicerad vid
Sidor 273-85
Språk en
Ämnesord Animals, DNA, Mitochondrial, genetics, Down-Regulation, genetics, Electron Transport, Embryo, Mammalian, metabolism, Embryonic Development, Gene Targeting, Genes, Essential, Hela Cells, Humans, Mice, Mice, Knockout, Mitochondria, pathology, Mitochondrial Proteins, metabolism, Myocardium, pathology, ultrastructure, Organ Specificity, Phenotype, Promoter Regions, Genetic, genetics, Protein Binding, RNA, Messenger, genetics, metabolism, Transcription Factors, metabolism, Transcription, Genetic
Ämneskategorier Kemi

Sammanfattning

Regulation of mammalian mtDNA gene expression is critical for altering oxidative phosphorylation capacity in response to physiological demands and disease processes. The basal machinery for initiation of mtDNA transcription has been molecularly defined, but the mechanisms regulating its activity are poorly understood. In this study, we show that MTERF3 is a negative regulator of mtDNA transcription initiation. The MTERF3 gene is essential because homozygous knockout mouse embryos die in midgestation. Tissue-specific inactivation of MTERF3 in the heart causes aberrant mtDNA transcription and severe respiratory chain deficiency. MTERF3 binds the mtDNA promoter region and depletion of MTERF3 increases transcription initiation on both mtDNA strands. This increased transcription initiation leads to decreased expression of critical promoter-distal tRNA genes, which is possibly explained by transcriptional collision on the circular mtDNA molecule. To our knowledge, MTERF3 is the first example of a mitochondrial protein that acts as a specific repressor of mammalian mtDNA transcription initiation in vivo.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?