Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12
| Författare |
Camilla Hörfelt Bo Stenquist Christina Halldin Marica B Ericson Ann-Marie Wennberg |
|---|---|
| Publicerad i | Acta Dermato-Venereologica |
| Volym | 89 |
| Nummer/häfte | 4 |
| Sidor | 372-378 |
| ISSN | 0001-5555 |
| Publiceringsår | 2009 |
| Publicerad vid |
Institutionen för fysik (GU) Institutionen för kliniska vetenskaper |
| Sidor | 372-378 |
| Språk | en |
| Länkar |
dx.doi.org/10.2340/00015555-0667 |
| Ämneskategorier | Dermatologi och venereologi |
This controlled study investigated single low-dose red light photodynamic therapy and methyl-aminolevulinate (MAL) for treatment of moderate to severe facial acne in 19 patients. The right cheek was treated with MAL (160 mg/g) for 3 h prior to illumination. The left cheek received red light only. Both cheeks were illuminated with narrow-band red light (635 nm) at a light dose of 15 J/cm(2). The global severity of acne was assessed at baseline and at follow-up, 10 and 20 weeks after treatment. Fluorescence images, clinical photographs and skin surface biopsies were obtained. Both MAL-photodynamic therapy and control areas showed a significant decrease in acne score at follow-up; no significant difference was found compared with control. MAL-photodynamic therapy was associated with adverse effects such as erythema and stinging. Fluorescence images revealed poor selectivity of MAL-induced fluorescence to the acne lesions, suggesting a general photoablating mechanism rather than selective destruction of sebaceous glands. No significant reduction in Propionibacterium acnes or sebum excretion was found.
GÖTEBORGS UNIVERSITET • Box 100 • 405 30 Göteborg • Telefon: 031 786 0000
Kontakt • Organisationsnummer: 202100-3153 • Om webbplatsen
Facebook
Twitter
Instagram
Youtube