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Effects of medetomidine on hepatic EROD activity in three species of fish

Artikel i vetenskaplig tidskrift
Författare Anna Lennquist
Malin C. Celander
Lars Förlin
Publicerad i Ecotoxicology and Environmental Safety
Volym 69
Nummer/häfte 1
Sidor 74-79
ISSN 0147-6513
Publiceringsår 2008
Publicerad vid Zoologiska institutionen
Zoologiska institutionen, zoofysiologi
Sidor 74-79
Språk en
Länkar doi:10.1016/j.ecoenv.2007.05.004
Ämnesord Medetomidine; Imidazole; a2-Adrenoceptor agonist; CYP1A; EROD; Antifouling; Fish
Ämneskategorier Toxikologi, Zoofysiologi, Marin ekologi

Sammanfattning

Medetomidine, an antifouling candidate, was investigated for its effects on cytochrome P4501A (CYP1A) activity in fish. Rainbow trout (Oncorhynchus mykiss), turbot (Psetta maxima), and Atlantic cod (Gadus morhua) were exposed to medetomidine either via i.p. injection (o5 mmol (1 mg)/kg) or via water (o50 nM). Enzyme activity was measured as ethoxyresorufin-O-deethylase (EROD) activity in liver microsomes. There was a small (2–7-fold) increase in EROD activity in rainbow trout. In turbot, EROD activity increased (4- fold) after injection, while a non-significant (50%) decrease was observed after water exposure. No effects on EROD activities were observed in Atlantic cod. In vitro inhibition studies of EROD activities in liver microsomes from all three species showed that medetomidine was a very potent CYP1A inhibitor. Thus, median inhibition values (IC50) were 35710nM for rainbow trout, 47717nM for turbot, and 111770nM for Atlantic cod. These observed effects suggest that medetomidine interferes with CYP1A-dependent metabolism of xenobiotics in these fish species.

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