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Differential presynaptic inhibition of actions of group II afferents in di- and polysynaptic pathways to feline motoneurones.

Artikel i vetenskaplig tidskrift
Författare Elzbieta Jankowska
U Slawinska
Ingela Hammar
Publicerad i The Journal of physiology
Volym 542
Nummer/häfte Pt 1
Sidor 287-99
ISSN 0022-3751
Publiceringsår 2002
Publicerad vid Institutionen för fysiologi och farmakologi
Sidor 287-99
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Cats, Electric Stimulation, Excitatory Postsynaptic Potentials, physiology, Female, Interneurons, physiology, Male, Motor Neurons, physiology, Neural Pathways, cytology, physiology, Neurons, Afferent, physiology, Posterior Horn Cells, physiology, Presynaptic Terminals, physiology, Skin, innervation, Synapses, physiology, Synaptic Transmission, physiology
Ämneskategorier Fysiologi

Sammanfattning

The aim of this study was to investigate differences in the effects of presynaptic inhibition of transmission from group II muscle afferents to neurones in the dorsal horn and in the intermediate zone and the consequences of these differences for reflex actions of group II afferents upon alpha-motoneurones. The degree of presynaptic inhibition was estimated from the degree of depression of monosynaptic components of population EPSPs (field potentials) evoked by group II muscle afferents in deeply anaesthetized cats. The decrease in the area of field potentials was considerably larger and longer lasting in the intermediate zone, where they were often obliterated, than in the dorsal horn, where they were reduced to about two-thirds. Presynaptic inhibition of field potentials evoked by other afferents at the same locations was much weaker. Intracellular records from alpha-motoneurones revealed that short latency EPSPs and IPSPs evoked from group II afferents are considerably reduced by conditioning stimuli that effectively depress intermediate zone field potentials of group II origin. The results of this study lead to the conclusion that strong presynaptic inhibition of transmission to intermediate zone interneurones allows a selective depression of disynaptic actions of group II muscle afferents on alpha- and gamma-motoneurones, mediated by these interneurones, and favours polysynaptic actions of these afferents.

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