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Urinary proteins in children with urinary tract infection

Artikel i vetenskaplig tidskrift
Författare Lena Andersson
Iulian Preda
Ulf Jodal
Mirjana Hahn-Zoric
Lars Åke Hanson
Rune Sixt
Lars Barregård
Sverker Hansson
Publicerad i Pediatric Nephrology
Volym 24
Nummer/häfte 8
Sidor 1533-1538
ISSN 0931-041X
Publiceringsår 2009
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Institutionen för kliniska vetenskaper
Sidor 1533-1538
Språk en
Länkar DOI 10.1007/s00467-009-1173-2
Ämnesord Alfa 1-microglobulin, biomarkör, Clara cell protein, C-reactive protein, scintigraphy, retinol binding protein
Ämneskategorier Pediatrik, Allmän medicin

Sammanfattning

Abstract The aim of this study was to test our hypothesis that the urinary excretion of C-reactive protein (CRP), alpha 1-microglobulin (A1M), retinol-binding protein (RBP) and Clara cell protein (CC16) is increased in children with urinary tract infection (UTI) and relates to renal damage as measured by acute dimercaptosuccinic acid (DMSA) scintigraphy. Fifty-two children <2 years of age with UTI were enrolled in the study, 44 of whom were febrile. The control group consisted of 23 patients with non-UTI infection and elevated serum CRP (s-CRP) levels. Thirty-six patients had abnormal DMSA uptake, classified as mild, moderate or severe damage (DMSA class 1, 2, 3, respectively). There was a significant association between DMSA class and the excretion of urinary RBP (u-RBP) and u-CC16. There was also a significant difference in u-CRP levels between children with UTI and control children with non-UTI infections, although u-CRP excretion was not significantly correlated to DMSA class. In conclusion, the urinary excretion of the low-molecular-weight proteins RBP and CC16 showed a strong association with uptake defects on renal DMSA scans. The urinary level of CRP seems to distinguish between children with UTI and other febrile conditions. A combination of these biomarkers may be useful in the clinical assessment of children with UTI.

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