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In vivo evaluation of noble metal coatings

Artikel i vetenskaplig tidskrift
Författare Felicia Suska
Sara Svensson
Anna Johansson
Lena Emanuelsson
Helen Karlholm
Mattias Ohrlander
Peter Thomsen
Publicerad i Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volym 92B
Nummer/häfte 1
Sidor 86-94
ISSN 1552-4981
Publiceringsår 2010
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Sidor 86-94
Språk en
Länkar dx.doi.org/10.1002/jbm.b.31492
Ämneskategorier Biomaterialvetenskap, Klinisk medicin

Sammanfattning

A nanotopographic noble metal (Ag, Au, Pd) coating has been applied on commercial urinary catheters and used in more than 80,000 patients, with good clinical results. We have previously evaluated the biocompatibility of different variations of this coating, showing high cellular viability and function in vitro. However, the reasons for good clinical and preclinical behavior are not known. This in vivo study aimed to investigate the soft tissue peri-implant reaction to five coatings with systematically altered noble metal ratios after 1, 3, and 21 days of implantation in rats. The results show that coatings of silver only, or silver with medium amounts of gold and low-medium palladium content were superior to other tested coatings. Such surfaces were during the first days after implantation associated with a decreased recruitment of inflammatory cells to implant close exudates, a lower percentage of neutrophils, higher cell viability, and lower production of monocyte chemoattractant protein-1 (MCP-1), compared to the other coatings and uncoated silicone (PDMS) control. In contrast, the addition of higher concentrations of gold and palladium to silver induced a thicker soft tissue capsule. Coatings with high concentration of palladium induced the thickest fibrouscapsule after 21 days of implantation. The study demonstrates that by varying the noble metal ratio at implant surfaces it is possible to modulate inflammation and fibrosis in soft tissue.

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