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Lack of evidence for an immunosuppressive role for MUC1.

Artikel i vetenskaplig tidskrift
Författare S Paul
N Bizouarne
A Paul
M R Price
Gunnar C. Hansson
M P Kieny
R B Acres
Publicerad i Cancer immunology, immunotherapy : CII
Volym 48
Nummer/häfte 1
Sidor 22-8
ISSN 0340-7004
Publiceringsår 1999
Publicerad vid Institutionen för medicinsk och fysiologisk kemi
Sidor 22-8
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord 3T3 Cells, immunology, metabolism, Amino Acid Sequence, Animals, Breast Neoplasms, immunology, metabolism, HL-60 Cells, immunology, metabolism, Hela Cells, Humans, Immunosuppressive Agents, isolation & purification, pharmacology, urine, Jurkat Cells, immunology, metabolism, Lymphocyte Activation, immunology, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Mucin-1, immunology, isolation & purification, urine, T-Lymphocytes, immunology, Tumor Cells, Cultured
Ämneskategorier Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Sammanfattning

The in vitro anti-proliferative properties of various supernatants from MUC1-expressing cell lines and of purified preparations of MUC1 were evaluated. We have observed that supernatants from the MUC1-and MUC3-positive cell line T47D, but not from the MUC1- and MUC4-positive cell line MCF7, were able to inhibit proliferation of cells from various haematopoietic cell lines. Although the activity of T47D supernatants could be abrogated by immunodepletion of MUC1, immunopurified MUC1 from T47D was unable to inhibit cell proliferation. Significantly, supernatants from mouse 3T3 cells transfected with a secreted form of MUC1 or from BHK-21 cells infected with a recombinant vaccinia virus coding for the secreted form of MUC1, as well as preparations of purified MUC1 from bile or urine, were likewise unable to inhibit T cell proliferation. Surprisingly, a crude mixture of bile mucins had a suppressive effect on T cell growth. Our results suggest that other molecules, such as amino sugars or other mucins, which can associate with MUC1, are likely to be responsible for the observed anti-proliferative effects of T47D cells.

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