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Infection by Helicobacter pylori in Bangladeshi children from birth to two years: relation to blood group, nutritional status, and seasonality.

Artikel i vetenskaplig tidskrift
Författare Taufiqur Rahman Bhuiyan
Firdausi Qadri
Amit Saha
Ann-Mari Svennerholm
Publicerad i The Pediatric infectious disease journal
Volym 28
Nummer/häfte 2
Sidor 79-85
ISSN 0891-3668
Publiceringsår 2009
Publicerad vid Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Sidor 79-85
Språk en
Länkar dx.doi.org/10.1097/INF.0b013e31818a...
Ämnesord Antibodies, Bacterial, blood, Antigens, Bacterial, isolation & purification, Bangladesh, epidemiology, Blood Group Antigens, Breast Feeding, Child, Preschool, Cohort Studies, Feces, microbiology, Female, Helicobacter Infections, blood, epidemiology, immunology, Helicobacter pylori, immunology, Humans, Immunoglobulin G, blood, Incidence, Infant, Infant, Newborn, Male, Nutritional Status, Poverty, Prevalence, Prospective Studies, Seasons, Urban Population
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

BACKGROUND: A birth cohort of 238 children was followed in an urban slum in Dhaka, Bangladesh, to determine incidence, prevalence, and epidemiologic factors related to Helicobacter pylori infection. METHODS: H. pylori infection was determined by a specific stool antigen test as well as enzyme-linked immunosorbent assay for detecting specific IgA and IgG antibodies in sera in children who completed 2 years of follow-up. RESULTS: Using the stool antigen test and serology, 50% and 60% of infants respectively, were positive for H. pylori by 2 years; an increase in the infection rate was seen after 6 months of age. Determination of specific antibodies in sera and detection of H. pylori antigen in stool were comparable. A typical seasonality, peaking in spring and autumn, was observed for acquisition of initial H. pylori infection. Children with blood group "A" were more susceptible to H. pylori infection than those with other ABO blood groups. Malnutrition did not seem to promote colonization by H. pylori. However, H. pylori-infected children were more often infected by multiple enteropathogens, often isolated at different time points. CONCLUSIONS: This study shows that noninvasive diagnostic methods such as serology and the stool antigen test are suitable for the study of acquisition of H. pylori infections in infants and can be used in field settings as well as in laboratories and clinical setting having less well equipped facilities. The study also shows seasonality for initial H. pylori infection and a relationship between blood group "A" and infection.

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