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Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins.

Artikel i vetenskaplig tidskrift
Författare Jessica A Brommelhoff
Margaret Gatz
Boo Johansson
John J McArdle
Laura Fratiglioni
Nancy L Pedersen
Publicerad i Psychology and aging
Volym 24
Nummer/häfte 2
Sidor 373-84
ISSN 0882-7974
Publiceringsår 2009
Publicerad vid Psykologiska institutionen
Sidor 373-84
Språk en
Länkar dx.doi.org/10.1037/a0015713
Ämnesord Age of Onset, Aged, Case-Control Studies, Dementia, diagnosis, epidemiology, genetics, Depressive Disorder, Major, diagnosis, epidemiology, genetics, Diseases in Twins, diagnosis, epidemiology, genetics, Female, Genetic Predisposition to Disease, Health Status, Humans, Logistic Models, Male, Prognosis, Questionnaires, Registries, statistics & numerical data, Risk Factors, Sweden, epidemiology, Twins, Dizygotic, genetics, Twins, Monozygotic, genetics
Ämneskategorier Psykologi

Sammanfattning

This study tested whether history of depression is associated with an increased likelihood of dementia, and whether a first depressive episode earlier in life is associated with increased dementia risk, or whether only depressive episodes close in time to dementia onset are related to dementia. Depression information came from national hospital discharge registries, medical history, and medical records. Dementia was diagnosed clinically. In case-control results, individuals with recent registry-identified depression were 3.9 times more likely than those with no registry-identified depression history to have dementia, whereas registry-identified depression earlier in life was not associated with dementia risk. Each 1-year increase in time between depression onset and dementia onset or equivalent age decreased the likelihood of dementia by 8.4%. In co-twin control analyses, twins with prior depression were 3.0 times more likely to have dementia than their nondepressed twin partners, with a similar age of depression gradient. These findings suggest that after partially controlling for genetic influences, late-life depression for many individuals may be a prodrome rather than a risk factor for dementia.

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