Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Liver-derived IGF1 enhanc… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Liver-derived IGF1 enhances the androgenic response in prostate.

Artikel i vetenskaplig tidskrift
Författare Johan Svensson
Jon Kindblom
Linus Ruijin Shao
Sofia Movérare-Skrtic
Marie Lagerquist
Niklas Andersson
Klara Sjögren
Katrien Venken
Dirk Vanderschueren
John-Olov Jansson
Olle Isaksson
Claes Ohlsson
Publicerad i The Journal of endocrinology
Volym 199
Nummer/häfte 3
Sidor 489-97
ISSN 1479-6805
Publiceringsår 2008
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning
Institutionen för medicin, avdelningen för invärtesmedicin
Institutionen för kliniska vetenskaper
Sidor 489-97
Språk en
Länkar dx.doi.org/10.1677/JOE-08-0406
Ämnesord Animals, Blotting, Western, Body Weight, drug effects, Dihydrotestosterone, pharmacology, Estradiol, blood, Immunohistochemistry, Insulin-Like Growth Factor I, genetics, metabolism, pharmacology, physiology, Male, Mice, Mice, Mutant Strains, Organ Size, drug effects, Prostate, drug effects, metabolism, Receptors, Androgen, genetics, metabolism, Reverse Transcriptase Polymerase Chain Reaction, Testosterone, blood
Ämneskategorier Endokrinologi

Sammanfattning

Both IGF1 and androgens are major enhancers of prostate growth and are implicated in the development of prostate hyperplasia and cancer. The aim of the present study was to investigate whether liver-derived endocrine IGF1 modulates the androgenic response in prostate. Mice with adult, liver-specific inactivation of IGF1 (LI-IGF1(-/-) mice) displayed an approximately 80% reduction in serum IGF1 levels associated with decreased prostate weight compared with control mice (anterior prostate lobe -19%, P<0.05; dorsolateral prostate (DLP) lobe -35%, P<0.01; ventral prostate (VP) lobe -47%, P<0.01). Reduced androgen receptor (Ar) mRNA and protein levels were observed in the VP lobe (-34% and -30% respectively, both P<0.05 versus control mice). Analysis of prostate morphology showed reductions in both the glandular and fibromuscular compartments of the VP and DLP lobes that were proportional to the reductions in the weights of these lobes. Immunohistochemistry revealed reduced intracellular AR immunoreactivity in the VP and DLP lobes. The non-aromatizable androgen dihydrotestosterone increased VP weight to a lesser extent in orchidectomized (ORX) LI-IGF1(-/-) mice than in ORX controls (-40%, P<0.05 versus control mice). In conclusion, deficiency of liver-derived IGF1 reduces both the glandular and fibromuscular compartments of the prostate, decreases AR expression in prostate, and reduces the stimulatory effect of androgens on VP weight. These findings may explain, at least in part, the well-known clinical association between serum IGF1 levels and conditions with abnormal prostate growth.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?