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The effect of alpha-interferon on bone marrow megakaryocytes and platelet production rate in essential thrombocythemia.

Artikel i vetenskaplig tidskrift
Författare Hans Wadenvik
Jack Kutti
Börje Ridell
Peter Revesz
Stefan Jacobsson
Bengt Magnusson
Jan Westin
Lars Vilén
Publicerad i Blood
Volym 77
Nummer/häfte 10
Sidor 2103-8
ISSN 0006-4971
Publiceringsår 1991
Publicerad vid Institutionen för laboratoriemedicin , Avdelningen för patologi
Institutionen för invärtesmedicin, Avdelningen för internmedicin
Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin
Sidor 2103-8
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Aged, Biopsy, Blood Cell Count, Blood Platelets, physiology, Bone Marrow Cells, Cell Division, Cell Nucleus, Cytoplasm, Female, Hematopoiesis, Humans, Indium Radioisotopes, diagnostic use, Interferon Type I, pharmacology, therapeutic use, Male, Megakaryocytes, physiology, Middle Aged, Thrombocythemia, Essential, blood, physiopathology, therapy
Ämneskategorier Tumörbiologi, Hematologi

Sammanfattning

In 10 patients with previously untreated essential thrombocythemia (ET), by using 111In-labeled platelets and megakaryocyte morphometry, the relation between platelet production rate and bone marrow megakaryocytes was evaluated before and during alpha-2b-interferon (IFN) therapy. A highly significant decrease in platelet count occurred during IFN therapy; the platelet counts, at baseline and after 2 and 6 months of IFN therapy, were 1,102 +/- 345 x 10(9)/L, 524 +/- 169 x 10(9)/L (P less than .0001), and 476 +/- 139 x 10(9)/L (P less than .0001), respectively. The decrement in platelet count was mainly a result of diminished platelet production rate, which at baseline and after 2 and 6 months of IFN therapy was 89 +/- 30 x 10(10) platelets/d, 53 +/- 18 x 10(10) platelets/d (P = .0033), and 45 +/- 20 x 10(10) platelets/d (P less than .0001), respectively. Also, a slight shortening of platelet mean life-span (MLS) was observed in response to IFN treatment; platelet MLS was 7.96 +/- 0.69 days at baseline and 6.68 +/- 1.30 days (P = .012) after 6 months of IFN therapy. IFN induced a significant decrease in bone marrow megakaryocyte volume; both megakaryocyte nuclear and cytoplasmatic volumes were affected. The mean megakaryocyte volume was 372 +/- 126 x 10(2) pL/microL at baseline and 278 +/- 147 x 10(2) pL/microL (P = .049) after 6 months of IFN therapy. However, the number of megakaryocytes did not show any significant change in response to IFN. It is concluded that alpha-IFN reduces platelet production rate and the peripheral platelet count in ET mainly through an anti-proliferative action on the megakaryocytes and to a considerably lesser degree by a shortening of platelet MLS.

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