Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Regulation of intestinal … - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Regulation of intestinal immunity: effects of the oral adjuvant Escherichia coli heat-labile enterotoxin on migrating dendritic cells.

Artikel i vetenskaplig tidskrift
Författare Simon W F Milling
Ulf Yrlid
Chris Jenkins
Claire M Richards
Neil A Williams
Gordon MacPherson
Publicerad i European journal of immunology
Volym 37
Nummer/häfte 1
Sidor 87-99
ISSN 0014-2980
Publiceringsår 2007
Publicerad vid Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Sidor 87-99
Språk en
Länkar dx.doi.org/10.1002/eji.200636199
Ämnesord Adjuvants, Immunologic, administration & dosage, Administration, Oral, Animals, Bacterial Toxins, administration & dosage, immunology, Cell Movement, immunology, Cells, Cultured, Dendritic Cells, cytology, immunology, transplantation, Enterotoxins, administration & dosage, immunology, Escherichia coli, immunology, Escherichia coli Proteins, administration & dosage, immunology, Immune Tolerance, Immunity, Mucosal, Intestinal Mucosa, cytology, immunology, transplantation, Lymph Nodes, cytology, immunology, Mesentery, Rats, Rats, Inbred Strains
Ämneskategorier Immunbiologi

Sammanfattning

Escherichia coli heat-labile enterotoxin (Etx) is an oral adjuvant in mice. We show that this is also true for rats. To understand this adjuvant activity we examined lymph dendritic cells (DC) migrating from the intestine to mesenteric lymph nodes (MLN) in animals fed Etx. These DC can prime antigen-specific antibody responses. We show that in rats the small intestine contains 7-24 million DC and 8 x 10(5 )of these migrate to MLN each day. Surprisingly, Etx does not stimulate increased migration of lymph DC. However, oral Etx affects the activation, antigen transport and localization of migratory DC. Specifically, expression of CD25 increases on the CD172a(high) subset of lymph DC. Oral Etx also increases the number of CD172a(high) lymph DC containing co-administered ovalbumin. CD172a(high) lymph DC treated with Etx in vitro, or purified from the lymph of animals fed Etx, stimulate stronger proliferative responses from primed T cells. Etx also directs more of the CD172a(high) lymph DC into the central region of the MLN T cell areas. This change in DC localization is associated with an increase in the expression of CCR7. These data help advance our understanding of the role of DC in initiating mucosal immune responses in vivo.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?