Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Steady-state migrating in… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Steady-state migrating intestinal dendritic cells induce potent inflammatory responses in naive CD4+ T cells.

Artikel i vetenskaplig tidskrift
Författare S W F Milling
C D Jenkins
Ulf Yrlid
V Cerovic
H Edmond
V McDonald
M Nassar
G Macpherson
Publicerad i Mucosal immunology
Volym 2
Nummer/häfte 2
Sidor 156-65
ISSN 1935-3456
Publiceringsår 2009
Publicerad vid Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Sidor 156-65
Språk en
Länkar dx.doi.org/10.1038/mi.2008.71
Ämnesord Animals, CD4-Positive T-Lymphocytes, immunology, Cell Movement, physiology, Cell Proliferation, Cells, Cultured, Cytokines, secretion, Dendritic Cells, immunology, physiology, Inflammation, immunology, Interferon-gamma, immunology, Lymph, immunology, Lymph Node Excision, methods, Lymphocyte Activation, immunology, Lymphocyte Culture Test, Mixed, methods, Lymphocytes, immunology, Male, Mesentery, immunology, surgery, Rats, Th1 Cells, immunology
Ämneskategorier Immunbiologi

Sammanfattning

Steady-state dendritic cells (DCs) migrating in the lymph from the intestine induce tolerance to harmless intestinal antigens, preventing inflammatory responses. To determine if such DCs are inherently tolerogenic we collected intestinal lymph DCs (L-DCs) by cannulation of the thoracic duct of rats after mesenteric lymphadenectomy, and examined their capacity to activate naive CD4+ lymphocytes in an allogeneic mixed leucocyte reaction. L-DCs stimulated strong proliferative responses, induced secretion of inflammatory cytokines including interferon-gamma, and induced FoxP3-positive lymphocytes to divide. To determine if the activated CD4+ T cells had been tolerized, they were rested and restimulated with irradiated splenocytes. The restimulated CD4+ T cells again proliferated and secreted inflammatory cytokines. These data demonstrate that the DCs, which migrate from the intestine in the steady state, are paradoxically able to induce strong inflammatory responses from naive T cells, despite their role in the maintenance of oral tolerance.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?