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Caries-related saliva properties in individuals with 22q11 deletion syndrome.

Artikel i vetenskaplig tidskrift
Författare Gunilla Klingberg
Peter Lingström
Sólveig Oskarsdóttir
Vanda Friman
Eva Bohman
Anette Carlén
Publicerad i Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Volym 103
Nummer/häfte 4
Sidor 497-504
ISSN 1528-395X
Publiceringsår 2007
Publicerad vid Institutionen för odontologi
Institutionen för biomedicin, avdelningen för infektionssjukdomar
Institutionen för kliniska vetenskaper
Sidor 497-504
Språk en
Länkar dx.doi.org/10.1016/j.tripleo.2006.0...
Ämnesord Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Chromosome Deletion, Chromosomes, Human, Pair 22, genetics, Dental Caries, blood, microbiology, Female, Humans, Immunoglobulin A, analysis, Male, Saliva, chemistry, secretion, Salivary Proteins and Peptides, analysis, Salivation, Statistics, Nonparametric, Syndrome
Ämneskategorier Cariologi, Oral mikrobiologi

Sammanfattning

OBJECTIVES: The aims were to compare saliva secretion rate, buffer capacity, cariogenic bacteria, total protein, IgA, and electrolytes between patients with 22q11 deletion syndrome (22q11DS) and control subjects and to study correlations between saliva and serum levels of IgA and electrolytes in 22q11DS patients. STUDY DESIGN: Twenty-nine consecutive 22q11DS patients (mean age 12.6 years) and matched healthy control subjects were clinically examined, and stimulated saliva samples were collected. RESULTS: Patients with 22q11DS had impaired salivary secretion rate (P < .01) and buffer capacity (P < .05), higher numbers of cariogenic bacteria (P < .01), increased saliva protein concentrations (P < .001), and reduced output of electrolytes (P < .001-.05) compared with control subjects. A correlation between concentration in serum and saliva was found only for IgA (r = .622; P < .01). CONCLUSIONS: Different salivary components were affected in patients with 22q11DS, which may explain the increased caries risk seen in these patients.

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