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Cell death-inducing DFF45-like effector C is reduced by caloric restriction and regulates adipocyte lipid metabolism.

Artikel i vetenskaplig tidskrift
Författare Björn Magnusson
Anders Gummesson
Camilla A M Glad
Julia H Goedecke
Margareta Jernås
Ted Lystig
Björn Carlsson
Björn Fagerberg
Lena M S Carlsson
Per-Arne Svensson
Publicerad i Metabolism: clinical and experimental
Volym 57
Nummer/häfte 9
Sidor 1307-13
ISSN 1532-8600
Publiceringsår 2008
Publicerad vid Wallenberglaboratoriet
Institutionen för medicin, avdelningen för invärtesmedicin
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 1307-13
Språk en
Länkar dx.doi.org/10.1016/j.metabol.2008.0...
Ämnesord 3T3-L1 Cells, Adipocytes, drug effects, metabolism, Adrenergic beta-Agonists, pharmacology, Adult, Animals, Caloric Restriction, Down-Regulation, Fatty Acids, metabolism, Fatty Acids, Nonesterified, metabolism, Female, Gene Silencing, Humans, Isoproterenol, pharmacology, Lipid Metabolism, Lipolysis, drug effects, Male, Mice, Middle Aged, Oxidation-Reduction, Protein Isoforms, metabolism, Proteins, genetics, metabolism, RNA, Small Interfering, pharmacology, Tissue Distribution
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

Members of the cell death-inducing DFF45-like effector (CIDE) gene family have been shown to regulate lipid metabolism. In this article, we report that the third member of the human CIDE family, CIDEC, is down-regulated in response to a reduced caloric intake. The down-regulation was demonstrated by microarray and real-time polymerase chain reaction analysis of subcutaneous adipose tissue in 2 independent studies on obese patients undergoing treatment with a very low calorie diet. By analysis of CIDEC expression in 65 human tissues, we conclude that human CIDEC is predominantly expressed in subcutaneous adipocytes. Together, these observations led us to investigate the effect of decreased CIDEC expression in cultured 3T3-L1 adipocytes. Small interfering RNA-mediated knockdown of CIDEC resulted in an increased basal release of nonesterified fatty acids, decreased responsiveness to adrenergic stimulation of lipolysis, and increased oxidation of endogenous fatty acids. Thus, we suggest that CIDEC is a regulator of adipocyte lipid metabolism and may be important for the adipocyte to adapt to changes in energy availability.

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