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Hyperinsulinemic rats are normotensive but sensitized to angiotensin II.

Artikel i vetenskaplig tidskrift
Författare Maria E Johansson
Irene J Andersson
Camilla Alexanderson
Ole Skøtt
Agneta Holmäng
Göran Bergström
Publicerad i American Journal of Physiology. Regulatory Integrative and Comparative Physiology (USA)
Volym 294
Nummer/häfte 4
Sidor R1240-7
ISSN 0363-6119
Publiceringsår 2008
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor R1240-7
Språk en
Länkar dx.doi.org/10.1152/ajpregu.00493.20...
Ämnesord Acetylcholine, pharmacology, Angiotensin II, metabolism, Angiotensin II Type 1 Receptor Blockers, pharmacology, Animals, Antihypertensive Agents, pharmacology, therapeutic use, Aorta, physiopathology, Blood Glucose, metabolism, Blood Pressure, drug effects, Blood Pressure Monitoring, Ambulatory, methods, Disease Models, Animal, Female, Ganglia, Sympathetic, drug effects, physiopathology, Ganglionic Blockers, pharmacology, Glucose, administration & dosage, Heart Rate, drug effects, Hexamethonium, pharmacology, Hyperinsulinism, chemically induced, complications, drug therapy, metabolism, physiopathology, Hypertension, drug therapy, etiology, metabolism, physiopathology, Insulin, administration & dosage, Insulin Infusion Systems, Losartan, pharmacology, therapeutic use, Myography, Rats, Rats, Sprague-Dawley, Renin, blood, Renin-Angiotensin System, drug effects, genetics, Telemetry, Time Factors, Vasodilation, Vasodilator Agents, pharmacology
Ämneskategorier Fysiologi

Sammanfattning

The effect of insulin on blood pressure (BP) is debated, and an involvement of an activated renin-angiotensin aldosterone system (RAAS) has been suggested. We studied the effect of chronic insulin infusion on telemetry BP and assessed sympathetic activity and dependence of the RAAS. Female Sprague-Dawley rats received insulin (2 units/day, INS group, n = 12) or insulin combined with losartan (30 mg.kg(-1).day(-1), INS+LOS group, n = 10), the angiotensin II receptor antagonist, for 6 wk. Losartan-treated (LOS group, n = 10) and untreated rats served as controls (n = 11). We used telemetry to measure BP and heart rate (HR), and acute ganglion blockade and air-jet stress to investigate possible control of BP by the sympathetic nervous system. In addition, we used myograph technique to study vascular function ex vivo. The INS and INS+LOS groups developed euglycemic hyperinsulinemia. Insulin did not affect BP but increased HR (27 beats/min on average). Ganglion blockade reduced mean arterial pressure (MAP) similarly in all groups. Air-jet stress did not increase sympathetic reactivity but rather revealed possible blunting of the stress response in hyperinsulinemia. Chronic losartan markedly reduced 24-h-MAP in the INS+LOS group (-38 +/- 1 mmHg P < 0.001) compared with the LOS group (-18 +/- 1 mmHg, P

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