Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Elevated levels of kynure… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia.

Artikel i vetenskaplig tidskrift
Författare L K Nilsson
K R Linderholm
G Engberg
Linda Paulson
Kaj Blennow
L H Lindström
C Nordin
A Karanti
P Persson
S Erhardt
Publicerad i Schizophrenia research
Volym 80
Nummer/häfte 2-3
Sidor 315-22
ISSN 0920-9964
Publiceringsår 2005
Publicerad vid Institutionen för klinisk neurovetenskap
Sidor 315-22
Språk en
Länkar dx.doi.org/10.1016/j.schres.2005.07...
Ämnesord Adolescent, Adult, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Kynurenic Acid, cerebrospinal fluid, Male, Middle Aged, Schizophrenia, cerebrospinal fluid, Severity of Illness Index
Ämneskategorier Farmaceutisk biokemi, Neurobiologi

Sammanfattning

Previous studies have shown that endogenous brain levels of kynurenic acid (KYNA), a glutamate receptor antagonist, are elevated in patients with schizophrenia. Here we analyse KYNA in the cerebrospinal fluid (CSF) from a large cohort, including male healthy controls (n=49) and male patients with schizophrenia (n=90). We found that male patients with schizophrenia had significantly higher levels of CSF KYNA compared to healthy male controls (1.45 nM+/-0.10 vs. 1.06 nM+/-0.06 in the control group). Furthermore, when the patients with schizophrenia were divided into subgroups we found that CSF KYNA levels were significantly elevated in drug-naïve, first episode patients (1.53 nM+/-0.19, n=37) and in patients undergoing treatment with antipsychotic drugs (1.53 nM+/-0.17, n=34) compared to healthy male controls. No elevated CSF KYNA levels were detected in drug-free patients with schizophrenia, i.e. patients previously undergoing antipsychotic medications but drug-free at time of sampling (1.16 nM+/-0.10, n=19). Present results confirm that CSF KYNA concentration is elevated in patients with schizophrenia and are consistent with the hypothesis that KYNA contributes to the pathophysiology of the disease.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?