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The risk of celiac disease in 107 families with at least two affected siblings.

Artikel i vetenskaplig tidskrift
Författare Audur Gudjonsdottir
Staffan Nilsson
Johan Ek
Bengt Kristiansson
Henry Ascher
Publicerad i Journal of pediatric gastroenterology and nutrition
Volym 38
Nummer/häfte 3
Sidor 338-42
ISSN 0277-2116
Publiceringsår 2004
Publicerad vid Institutionen för matematisk statistik
Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 338-42
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adolescent, Adult, Aged, Autoantibodies, analysis, blood, Biological Markers, blood, Celiac Disease, blood, epidemiology, genetics, Child, Child, Preschool, Female, Genetic Predisposition to Disease, Humans, Infant, Male, Middle Aged, Norway, epidemiology, Pedigree, Prevalence, Risk Assessment, Risk Factors, Sex Factors, Sweden, epidemiology
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

OBJECTIVES: Screening for celiac disease (CD) in the apparently healthy members of 107 nuclear families with two affected siblings (sib pair) and estimating the risk of CD in siblings and parents. METHODS: One hundred seven families from Sweden and southern Norway with at least two affected children were investigated. Frozen sera from 187 of the 192 healthy parents and from 94 of 95 siblings without diagnosed CD were examined for total immunoglobulin A (IgA) and anti-endomysial antibodies (EMA). Individuals with positive antibody titers underwent small intestinal biopsy. RESULTS: Positive test for EMA was found in 6 of 94 (6.3%) siblings without previously diagnosed CD and in 8 of 189 (4.2%) parents. CD was confirmed by small intestinal biopsy in all siblings and seven parents. The estimated risk for CD in multiply affected families was 26.3% for siblings and 12.9% for parents. An unexpected male preponderance was found among the new CD cases (10 males, 3 females). CONCLUSION: The risk of CD in the members of nuclear families with two affected children is approximately three times higher than that when only one child is affected. The high male preponderance of new cases is unexpected and could not be explained fully by more silent disease in males as compared with females. Considering the high level of knowledge about CD in these families, the number of undiagnosed cases is surprisingly high. The authors suggest that serologic screening should be offered to all first-degree relatives of patients with CD.

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