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A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women.

Artikel i vetenskaplig tidskrift
Författare Jonas Melke
Lars Westberg
Staffan Nilsson
Mikael Landén
Henrik Söderström
Fariba Baghaei
Roland Rosmond
Göran Holm
Per Björntorp
Lars-Göran Nilsson
Rolf Adolfsson
Elias Eriksson
Publicerad i Archives of general psychiatry
Volym 60
Nummer/häfte 10
Sidor 1017-23
ISSN 0003-990X
Publiceringsår 2003
Publicerad vid Institutionen för matematisk statistik
Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi
Institutionen för klinisk neurovetenskap, Sektionen för psykiatri
Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi
Sidor 1017-23
Språk en
Länkar dx.doi.org/10.1001/archpsyc.60.10.1...
Ämnesord Adult, Cohort Studies, Female, Genotype, Humans, Middle Aged, Personality, classification, genetics, Personality Assessment, Personality Inventory, Polymorphism, Genetic, genetics, Receptors, Serotonin, 5-HT3, genetics, Serine Endopeptidases, genetics, Sweden
Ämneskategorier Medicin och Hälsovetenskap, Psykiatri

Sammanfattning

BACKGROUND: The brain neurotransmitter serotonin is known to affect various aspects of human behavior, including personality traits. Serotonin receptor type 3 is a ligand-gated channel encoded by 2 different subunit genes, HTR3A and HTR3B. A polymorphism (C178T) in the 5' region of the HTR3A gene has recently been identified and suggested to be of functional importance. OBJECTIVE: To elucidate the possible association between the C178T polymorphism in the HTR3A gene and personality traits in women. DESIGN: Two independent samples of 35- to 45-year-old Swedish women were recruited using the population register. Sample 1 (n = 195) was assessed via the Karolinska Scales of Personality and the Temperament and Character Inventory; sample 2 (n = 175) was assessed using the latter only. Both samples were genotyped with respect to the C178T polymorphism in the HTR3A gene. The A1596G polymorphism in the same gene was also investigated. RESULTS: A significant association between C178T genotype and the Temperament and Character Inventory factor harm avoidance was observed in sample 1 (corrected for multiple comparisons P =.04); this finding was subsequently replicated in sample 2 (P =.004) (pooled populations: P<.001). In the pooled sample, all harm avoidance subscales were found to be significantly associated with the C178T polymorphism: anticipatory worry (P =.001), fear of uncertainty (P<.001), shyness (P<.001), and fatigability and asthenia (P =.008). In addition, a significant association was found in sample 1 between the C178T polymorphism and the Karolinska Scales of Personality nonconformity factor (corrected P =.002), including the subscales of social desirability (P<.001), indirect aggression (P =.002), verbal aggression (P =.05), and irritability (P<.001). Participants homozygous for the less common T allele (<4%) differed from the remaining women by displaying lower ratings on harm avoidance and nonconformity. CONCLUSION: The C178T polymorphism in the HTR3A gene may affect the personality trait of harm avoidance in women.

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