Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Investigation of transcri… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Investigation of transcription factor AP-2 beta genotype in women with premenstrual dysphoric disorder.

Artikel i vetenskaplig tidskrift
Författare Mattias Damberg
Lars Westberg
Cecilia Berggård
Mikael Landén
Charlotta Sundblad-Elverfors
Olle Eriksson
Tord Naessén
Agneta Ekman
Elias Eriksson
Publicerad i Neuroscience letters
Volym 377
Nummer/häfte 1
Sidor 49-52
ISSN 0304-3940
Publiceringsår 2005
Publicerad vid Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi
Institutionen för klinisk neurovetenskap, Sektionen för psykiatri
Sidor 49-52
Språk en
Länkar dx.doi.org/10.1016/j.neulet.2004.11...
Ämnesord Adolescent, Adult, DNA-Binding Proteins, genetics, Depressive Disorder, genetics, psychology, Female, Genotype, Humans, Middle Aged, Premenstrual Syndrome, genetics, psychology, Transcription Factor AP-2, Transcription Factors, genetics
Ämneskategorier Fysiologi

Sammanfattning

It has repeatedly been shown that the serotonergic system is involved in the symptomatology of premenstrual dysphoric disorder (PMDD). Women with PMDD are reported to differ from symptom-free controls with regard to serotonin-related biological markers. Evidence from family and twin studies suggests a genetic contribution to the aetiology of PMDD. The expression of human transcription factor AP-2beta in neural crest cell lineages and neuroectodermal cells suggests that this protein may be of importance for functional characteristics of neurons by regulating the expression of target genes. Within the monoaminergic systems, several genes have binding sites for AP-2beta in regulatory regions, suggesting an involvement of AP-2beta in these systems. The gene encoding AP-2beta is located on chromosome 6p12-p21.1 and includes a polymorphic region consisting of a variable number of [CAAA] repeats located in the second intron. We have earlier shown that AP-2beta genotype is associated with serotonergic phenotypes and that brainstem levels of AP-2beta correlate positively to serotonin metabolism in rat frontal cortex. The aim of this study was to investigate the relationship between PMDD and transcription factor AP-2beta genotype. The participants included 176 women with PMDD and 91 healthy controls. Genotyping was performed by polymerase chain reactions. We did not observe any differences in AP-2beta genotype frequencies between PMDD subjects and controls. Our results suggest that AP-2beta genotype is not a risk factor for PMDD. To our knowledge, this is the first study investigating transcription factor AP-2beta genotype in women with PMDD. Hence, these results should be considered preliminary until replicated.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?