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Tumor necrosis factor gene polymorphisms and inflammatory response in coronary artery bypass grafting patients.

Artikel i vetenskaplig tidskrift
Författare Martin Westerberg
Anders Bengtsson
Anne Ricksten
Anders Jeppsson
Publicerad i Scandinavian cardiovascular journal : SCJ
Volym 38
Nummer/häfte 5
Sidor 312-7
ISSN 1401-7431
Publiceringsår 2004
Publicerad vid Hjärt-kärlinstitutionen
Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin
Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård
Sidor 312-7
Språk en
Länkar dx.doi.org/10.1080/1401743041003179...
Ämnesord Aged, Alleles, Coronary Arteriosclerosis, genetics, surgery, Coronary Artery Bypass, Female, Humans, Inflammation, genetics, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, Tumor Necrosis Factor-alpha, genetics
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha), a key factor in the inflammatory cascade, has been implicated in coronary artery disease. Two biallelic polymorphisms in the TNF gene locus (TNFA at position -308 and TNFB at +252) may influence TNF-alpha production. Individuals with the rare TNFA2 allele or TNFB2 homozygosity have augmented TNF-alpha production. We investigated the genotypes associated with increased TNF-alpha production in coronary artery bypass grafting (CABG) patients and if these genotypes influence the magnitude of the postoperative inflammatory response. METHODS: TNF gene polymorphisms were analyzed by multiplex fluorescent solid-phase minisequencing in 86 CABG patients. Plasma concentrations of TNF-alpha, IL-6 and C3a and C-reactive protein (CRP) were analyzed before and after surgery in 45 of the patients and compared with genetically high and low TNF-alpha producers. RESULTS: Thirty percent of the patients carried the TNFA2 allele and 45% were TNFB2 homozygous. The allelic frequencies were TNFA1/TNFA2 = 0.84/0.16 and TNFB1/TNFB2 = 0.32/0.68. Pre- and postoperative levels of TNF-alpha, IL-6, C3a and CRP did not differ significantly between genetically high and low TNF-alpha producers. CONCLUSIONS: The frequency of high TNF-alpha producing genotypes in a CABG population was comparable to that previously reported from normal populations. Furthermore, we found no evidence that the investigated TNF-alpha gene polymorphisms influence postoperative inflammatory response after uncomplicated coronary surgery.

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