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Immature porcine knee cartilage lesions show good healing with or without autologous chondrocyte transplantation.

Artikel i vetenskaplig tidskrift
Författare Anna I Vasara
M M Hyttinen
M J Lammi
O Pulliainen
Jukka S Jurvelin
Lars Peterson
Anders Lindahl
H J Helminen
Ilkka Kiviranta
Publicerad i Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Volym 14
Nummer/häfte 10
Sidor 1066-74
ISSN 1063-4584
Publiceringsår 2006
Publicerad vid Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin
Sidor 1066-74
Språk en
Länkar dx.doi.org/10.1016/j.joca.2006.04.0...
Ämnesord Animals, Cartilage, Articular, injuries, surgery, Chondrocytes, transplantation, Collagen Type II, chemistry, Glycosaminoglycans, chemistry, Hindlimb, Hyaluronic Acid, chemistry, Knee Joint, surgery, Periosteum, transplantation, Swine, Transplantation, Autologous, Wound Healing
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

OBJECTIVE: The purpose of this study was to find out how deep chondral lesions heal in growing animals spontaneously and after autologous chondrocyte transplantation. METHODS: A 6mm deep chondral lesion was created in the knee joints of 57 immature pigs and repaired with autologous chondrocyte transplantation covered with periosteum or muscle fascia, with periosteum only, or left untreated. After 3 and 12 months, the repair tissue was evaluated with International Cartilage Repair Society (ICRS) macroscopic grading, modified O'Driscoll histological scoring, and staining for collagen type II and hyaluronan, and with toluidine blue and safranin-O staining for glycosaminoglycans. The repair tissue structure was also examined with quantitative polarized light microscopy and indentation analysis of the cartilage stiffness. RESULTS: The ICRS grading indicated nearly normal repair tissue in 65% (10/17) after the autologous chondrocyte transplantation and 86% (7/8) after no repair at 3 months. At 1 year, the repair tissue was nearly normal in all cases in the spontaneous repair group and in 38% (3/8) in the chondrocyte transplantation group. In most cases, the cartilage repair tissue stained intensely for glycosaminoglycans and collagen type II indicating repair tissue with true constituents of articular cartilage. There was a statistical difference in the total histological scores at 3 months (P=0.028) with the best repair in the spontaneous repair group. A marked subchondral bone reaction, staining with toluidine blue and collagen type II, was seen in 65% of all animals. CONCLUSIONS: The spontaneous repair ability of full thickness cartilage defects of immature pigs is significant and periosteum or autologous chondrocytes do not bring any additional benefits to the repair.

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