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Indentation stiffness of repair tissue after autologous chondrocyte transplantation.

Artikel i vetenskaplig tidskrift
Författare Anna I Vasara
Miika T Nieminen
Jukka S Jurvelin
Lars Peterson
Anders Lindahl
Ilkka Kiviranta
Publicerad i Clinical orthopaedics and related research
Nummer/häfte 433
Sidor 233-42
ISSN 0009-921X
Publiceringsår 2005
Publicerad vid Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi
Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin
Sidor 233-42
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adolescent, Adult, Arthroscopy, methods, Cartilage Diseases, pathology, surgery, Cartilage, Articular, injuries, pathology, Cell Transplantation, adverse effects, methods, Chondrocytes, transplantation, Cohort Studies, Female, Follow-Up Studies, Graft Rejection, Graft Survival, Humans, Injury Severity Score, Knee Injuries, diagnosis, therapy, Magnetic Resonance Imaging, Male, Middle Aged, Osteochondritis Dissecans, diagnosis, Probability, Range of Motion, Articular, physiology, Recovery of Function, Retrospective Studies, Risk Assessment, Statistics, Nonparametric, Transplantation, Autologous, Treatment Outcome
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

Our main hypothesis was that indentation stiffness of the repair tissue approaches the values of adjacent cartilage 1 year after autologous chondrocyte transplantation. We also wanted to investigate the differences between osteochondritic lesions and full-thickness lesions. Thirty patients with cartilage lesions were operated on with autologous chondrocyte transplantation. The repair was evaluated arthroscopically, indentation stiffness was measured, and clinical evaluations were done. The stiffness of the repair tissue improved to 62% (mean 2.04 +/- 0.83 N, mean +/- SD) of adjacent cartilage (3.58 +/- 1.04 N). Fifty-three percent of the patients graded their knee as excellent or good and 47% of the patients graded their knee as fair at the followup. In six patients the normalized stiffness was at least 80%, suggesting hyaline-like repair. The indentation stiffness of the osteochondritis dissecans lesion repairs (1.45 +/- 0.46 N; n = 7) was less than that of the nonosteochondritis dissecans lesion repair sites (2.37 +/- 0.72 N; n = 19). Gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC) during followup of four patients suggested proteoglycan replenishment, although all grafts showed low indentation values. Low stiffness values may indicate incomplete maturation or predominantly fibrous repair. The indentation analysis showed that the repair tissue stiffness could, in some cases, reach the same level as the adjacent cartilage, but there was a large variation among the grafts.

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