Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

MHC expression and chemok… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

MHC expression and chemokine production in the murine vagina following intra-vaginal administration of ligands to toll-like receptors 3, 7 and 9

Artikel i vetenskaplig tidskrift
Författare Merja Nurkkala
Inger Nordström
Esbjörn Telemo
Kristina Eriksson
Publicerad i J Reprod Immunol
Volym 73
Nummer/häfte 2
Sidor 148-57
ISSN 0165-0378 (Print)
Publiceringsår 2007
Publicerad vid Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning
Sidor 148-57
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adjuvants, Immunologic/*pharmacology, Aminoquinolines/pharmacology, Animals, Antigens, CD11c/immunology/metabolism, Chemokines/*biosynthesis/immunology, Dendritic Cells/cytology/immunology/metabolism, Female, Histocompatibility Antigens/*biosynthesis/immunology, Interferon Inducers/*pharmacology, Leukocytes/cytology/immunology/metabolism, Ligands, Mice, Oligodeoxyribonucleotides/*pharmacology, Poly I-C/*pharmacology, Time Factors, Toll-Like Receptors/*agonists/immunology/metabolism, Up-Regulation/drug effects/immunology, Vagina/cytology/immunology/*metabolism
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

The expression of MHC class I, MHC class II and the chemokines IP-10, MIP-1alpha, RANTES, fractalkine and I-TAC has been analyzed after intra-vaginal treatment with three synthetic toll-like receptors (TLR) agonists-double-stranded RNA (poly I:C), imiquimod and CpG-rich oligonucleotides (CpG-ODN). These compounds act mainly through TLR3, TLR7 and TLR9, respectively. CpG-ODN induced an accumulation of leucocytes in the vagina, and a strong up-regulation of MHC class I expression on both leucocytes and epithelial cells. Imiquimod and poly I:C induced a weak MHC class I up-regulation in the epithelium but not in the lamina propria. Neither treatment had any profound effect on expression of MHC class II on epithelial cells but poly I:C and to a lesser extent CpG-ODN, up-regulated MHC class II staining intensity which, in the case of CpG-ODN, treatment, was associated with a strong accumulation of CD11c-positive dendritic cells. All three treatments induced an early (8h) but transient IP-10 response. Imiquimod and CpG-ODN, but not poly I:C induced an early MIP-1alpha response which remained for at least 7 days in CpG-ODN-treated animals but not in imiquimod-treated mice. Poly I:C and CpG-ODN, but not imiquimod, induced significant levels of RANTES at different time-points post-treatment. None of the treatments induced any significant changes in the levels of fractalkine, I-TAC or IFN-alpha. These studies have implications for the manipulation of the genital immune response and also improving the outcome of vaginal immunotherapy.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?