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A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell functions

Artikel i vetenskaplig tidskrift
Författare Lars Bellner
Fredrik Bergh Thorén
Erik Nygren
Jan-Åke Liljeqvist
Anna Karlsson
Kristina Eriksson
Publicerad i J Immunol
Volym 174
Nummer/häfte 4
Sidor 2235-41
Publiceringsår 2005
Publicerad vid Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning
Institutionen för medicinsk mikrobiologi och immunologi
Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi
Sidor 2235-41
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Amino Acid Sequence, Apoptosis/immunology, Chemotaxis, Leukocyte/immunology, Cytotoxicity, Immunologic/immunology, Enzyme Induction/immunology, Herpesvirus 2, Human/*immunology, Humans, Immunosuppressive Agents/chemical synthesis/immunology, Inflammation Mediators/chemical synthesis/*physiology, Killer Cells, Natural/*immunology/pathology/virology, Macrophage Activation/immunology, Molecular Sequence Data, Monocytes/*immunology/pathology/virology, NADPH Oxidase/biosynthesis/metabolism, Neutrophil Activation/immunology, Neutrophils/enzymology/*immunology/pathology/virology, Peptide Fragments/chemical synthesis/*physiology, Pertussis Toxin/pharmacology, Phagocytes/enzymology/immunology/pathology/virology, Reactive Oxygen Species/metabolism, Receptors, Formyl Peptide/physiology, Research Support, Non-U.S. Gov't, Viral Envelope Proteins/chemical synthesis/*physiology
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

We have identified a synthetic peptide derived from the secreted portion of HSV type 2 glycoprotein G, denoted gG-2p20, which has proinflammatory properties in vitro. The gG-2p20 peptide, corresponding to aa 190-205 of glycoprotein G-2, was a chemoattractant for both monocytes and neutrophils in a dose-dependent fashion, and also induced the release of reactive oxygen from these cells. The receptor mediating the responses was identified as the formyl peptide receptor. The gG-2p20-induced activation of phagocytes had a profound impact on NK cell functions. The reactive oxygen species produced by gG-2p20-activated phagocytes both inhibited NK cell cytotoxicity and accelerated the apoptotic cell death in NK cell-enriched lymphocyte populations. Hence, we have for the first time been able to identify a potential function of the secreted portion of HSV-2 glycoprotein G. We propose that the proinflammatory gG-2p20 peptide identified could contribute to a reduced function and viability of NK cells during HSV-2 infection due to its ability to recruit and activate phagocytic cells.

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