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Nonmedical Factors and Health-Related Quality of Life in CKD in India

Artikel i vetenskaplig tidskrift
Författare G. K. Modi
A. K. Yadav
A. Ghosh
K. Kamboj
P. Kaur
V. Kumar
S. Bhansali
N. Prasad
M. Sahay
S. Parameswaran
S. Varughese
S. Gang
S. Singh
D. Sircar
N. Gopalakrishnan
A. Jaryal
S. Vikrant
Seema Baid-Agrawal
V. Jha
Publicerad i Clinical Journal of the American Society of Nephrology
Volym 15
Nummer/häfte 2
Sidor 191-199
ISSN 1555-9041
Publiceringsår 2020
Publicerad vid Institutionen för medicin
Sidor 191-199
Språk en
Länkar dx.doi.org/10.2215/cjn.06510619
Ämnesord chronic kidney disease, quality of life, KDQOL, humans, female, albuminuria, patient reported outcome measures, clinical decision, making, factor V, prospective studies, noncommunicable diseases, chronic, renal insufficiency, socioeconomic factors, glomerular filtration rate, diabetes mellitus, hypertension, occupations, India, chronic kidney-disease, outcomes, adults, Urology & Nephrology
Ämneskategorier Urologi och njurmedicin

Sammanfattning

Background and objectivesPatient-reported outcomes have gained prominence in the management of chronic noncommunicable diseases. Measurement of health-related quality of life is being increasingly incorporated into medical decision making and health care delivery processes.Design, setting, participants, & measurementsThe Indian Chronic Kidney Disease Study is a prospective cohort of participants with mild to moderate CKD. Baseline health-related quality of life scores, determined by the standardized Kidney Disease Quality of Life 36 item instrument, are presented for the inception cohort (n=2919). Scores are presented on five subscales: mental component summary, physical component summary, burden, effect of kidney disease, and symptom and problems; each is scored 0?100. The associations of socioeconomic and clinical parameters with the five subscale scores and lower quality of life (defined as subscale score <1 SD of the sample mean) were examined. The main socioeconomic factors studied were sex, education, occupation, and income. The key medical factors studied were age, eGFR, diabetes, hypertension, and albuminuria.ResultsThe mean (SD) subscale scores were physical component summary score, 43?9; mental component summary score, 48?10; burden, 61?33; effects, 87?13; and symptoms, 90?20. Among the socioeconomic variables, women, lower education, and lower income were negatively associated with reduced scores across all subscales. For instance, the respective ?-coefficients (SD) for association with the physical component summary subscale were ?2.6 (?3.4 to ?1.8), ?1.5 (?2.2 to ?0.7), and ?1.6 (?2.7 to ?0.5). Medical factors had inconsistent or no association with subscale scores. The quality of life scores also displayed regional variations.ConclusionsIn this first of its kind analysis from India, predominantly socioeconomic factors were associated with quality of life scores in patients with CKD.

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