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The Origin of the Cerebral Palsies: Contribution of Population-Based Neuroimaging Data

Artikel i vetenskaplig tidskrift
Författare V. Horber
E. Sellier
K. Horridge
G. Rackauskaite
G. L. Andersen
D. Virella
E. Ortibus
I. Dakovic
O. Hensey
A. Radsel
A. Papavasiliou
J. De la Cruz
C. Arnaud
I. Krageloh-Mann
Kate Himmelmann
Publicerad i Neuropediatrics
Volym 51
Nummer/häfte 2
Sidor 113-119
ISSN 0174-304X
Publiceringsår 2020
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 113-119
Språk en
Länkar dx.doi.org/10.1055/s-0039-3402007
Ämnesord magnetic resonance imaging, classification, cerebral palsy, children, lesions, reliability, prevalence, injury, system, born, mri, Neurosciences & Neurology, Pediatrics
Ämneskategorier Neurovetenskaper, Pediatrik

Sammanfattning

Background Surveillance of cerebral palsy in Europe (SCPE) presents the first population-based results on neuroimaging findings in children with cerebral palsy (CP) using a magnetic resonance imaging classification system (MRICS). Method MRIs of children with CP born between 1999 and 2009 from 18 European countries were analyzed. MRICS identifies patterns of brain pathology according to timing during brain development which was analyzed with respect to CP subtypes and gestational age. Results MRIs or written reports from 3,818 children were available. The main clinical characteristics were similar to the 5,415 without such data. Most frequent was predominant white matter injury (49%), followed by predominant gray matter injury (21%). Maldevelopments were found in 11% of cases. Miscellaneous findings were present in 8.5% and normal findings in 10.6%. MRI patterns of children with unilateral spastic, bilateral spastic, and dyskinetic CP were mainly lesional (77, 71, and 59%, respectively), whereas children with ataxic CP had more maldevelopments, miscellaneous, and normal findings (25, 21, and 32%, respectively). In children born preterm, predominant white matter injury was most prevalent (80% in children born <32 weeks of gestation). Conclusion Analysis of MRI in the European CP database identified CP as a mainly lesional condition on a large population basis, maldevelopments were relatively uncommon. An exception was ataxic CP. Children born preterm mostly presented with a lesion typical for their gestational age (GA) at birth. The decreasing prevalence of CP in this group suggests that progress in perinatal and neonatal medicine may lead to a reduction of these lesions.

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