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Immediate clinical and microbiological evaluation of the effectiveness of 0.5% versus 3% sodium hypochlorite in root canal treatment: A quasi-randomized controlled trial.

Artikel i vetenskaplig tidskrift
Författare Charlotte Ulin
M Magunacelaya-Barria
Gunnar Dahlén
Thomas Kvist
Publicerad i International endodontic journal
ISSN 1365-2591
Publiceringsår 2019
Publicerad vid Institutionen för odontologi, sektion 1
Institutionen för odontologi, sektion 3
Språk en
Länkar dx.doi.org/10.1111/iej.13258
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Endodonti, Oral mikrobiologi

Sammanfattning

To test the hypothesis that in the daily routine of a specialist clinic in endodontics that irrigation during root canal preparation with 3.0% NaOCl will result in fewer postoperative samples with cultivable bacteria than irrigation with 0.5% buffered NaOCl but, at the same time, will not result in a higher frequency of postoperative pain nor swelling.Two hundred ninety-eight patients were enrolled in the study and were randomly assigned into two groups - 0.5% NaOCl and 3% NaOCl. All endodontic diagnoses were included. Root canal treatment was performed, and bacterial sampling was carried out prior to root filling. The patients were requested to complete a form regarding pain and swelling seven days postoperatively. Fisher's exact test, Mann-Whitney U-test, Mantel-Haenszel chi-squared and the chi-squared test with a significance level of P < 0.05 were used for statistical analysis. Multivariable logistic regression was used to adjust for confounders.In the 0.5% NaOCl group, 18 (13.4%) of the root canal samples were positive; in the 3% NaOCl group, the corresponding number was 24 (18.6%). The mean difference of -5.2% (95% CI: -14.8 to 4.4) was not significant (P = 0.33). In the 0.5% NaOCl group, 57 (53.8%) patients reported some pain; in the 3% group, the corresponding number was 56 (53.3%). The mean difference of 0.4 (95% CI: -14.0 to 14.8) was not significant (P = 1.0). In the 0.5% NaOCl group, 5 (5.1%) patients reported swelling; in the 3% NaOCl group, the corresponding number was 18 (17.8%). The mean difference was 12.7 (95% CI: 3.1-22.4), which was significant (P = 0.0084).The difference in the concentration of NaOCl (0.5% vs 3%) had no significant impact on the number of positive cultures and did not influence either the frequency or the magnitude of postoperative pain. A significantly higher incidence of postoperative swelling was recorded for patients who received a greater concentration of NaOCl (3%).

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