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Gait speed as predictor of transition into cognitive impairment: Findings from three longitudinal studies on aging

Artikel i vetenskaplig tidskrift
Författare Emiel O. Hoogendijk
Judith J.M. Rijnhart
Johan Skoog
Annie Robitaille
Ardo van den Hout
Luigi Ferrucci
Martijn Huisman
Ingmar Skoog
Andrea M. Piccinin
Scott M. Hofer
Graciela Muniz Terrera
Publicerad i Experimental Gerontology
Volym 129
ISSN 0531-5565
Publiceringsår 2020
Publicerad vid Institutionen för neurovetenskap och fysiologi
Psykologiska institutionen
Centrum för åldrande och hälsa (AgeCap)
Språk en
Länkar https://doi.org/10.1016/j.exger.201...
Ämnesord Cognition, Dementia, Multistate modeling, Walking speed
Ämneskategorier Äldre och åldrande, Psykologi

Sammanfattning

© 2019 The Authors Objectives: Very few studies looking at slow gait speed as early marker of cognitive decline investigated the competing risk of death. The current study examines associations between slow gait speed and transitions between cognitive states and death in later life. Methods: We performed a coordinated analysis of three longitudinal studies with 9 to 25 years of follow-up. Data were used from older adults participating in H70 (Sweden; n = 441; aged ≥70 years), InCHIANTI (Italy; n = 955; aged ≥65 years), and LASA (the Netherlands; n = 2824; aged ≥55 years). Cognitive states were distinguished using the Mini-Mental State Examination. Slow gait speed was defined as the lowest sex-specific quintile at baseline. Multistate models were performed, adjusted for age, sex and education. Results: Most effect estimates pointed in the same direction, with slow gait speed predicting forward transitions. In two cohort studies, slow gait speed predicted transitioning from mild to severe cognitive impairment (InCHIANTI: HR = 2.08, 95%CI = 1.40–3.07; LASA: HR = 1.33, 95%CI = 1.01–1.75) and transitioning from a cognitively healthy state to death (H70: HR = 3.30, 95%CI = 1.74–6.28; LASA: HR = 1.70, 95%CI = 1.30–2.21). Conclusions: Screening for slow gait speed may be useful for identifying older adults at risk of adverse outcomes such as cognitive decline and death. However, once in the stage of more advanced cognitive impairment, slow gait speed does not seem to predict transitioning to death anymore.

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