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Effect of Macronutrient Type and Gastrointestinal Release Site on PYY Response in Normal Healthy Subjects

Artikel i vetenskaplig tidskrift
Författare A. M. Mangan
W. Al Najim
N. McNamara
W. P. Martin
A. Antanaitis
S. B. Bleiel
R. M. Kent
C. W. le Roux
Neil G. Docherty
Publicerad i Journal of Clinical Endocrinology & Metabolism
Volym 104
Nummer/häfte 9
Sidor 3661-3669
ISSN 0021-972X
Publiceringsår 2019
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning
Sidor 3661-3669
Språk en
Länkar dx.doi.org/10.1210/jc.2018-01697
Ämnesord enteroendocrine cells, gut hormone, peptide yy, eating behavior, weight-loss, food-intake, appetite, satiety
Ämneskategorier Klinisk medicin

Sammanfattning

Background and Aims: Enteroendocrine L cells release satiety inducing hormones in response to stimulation by luminal macronutrients. We sought to profile the differential effect of macronutrient type and site of release on circulating concentrations of the L cell-derived enteroendocrine hormone peptide tyrosine tyrosine (amino acids 1 to 36) (PYY). Materials and Methods: Eight healthy volunteers were recruited to a randomized, double-blinded, six-way crossover study. At each visit, the participants consumed a 500-kcal drink containing carbohydrate, protein, or fat in either gastric or small intestinal release formulations. Plasma PYY concentrations and hunger ratings were assessed for 3 hours after consumption of the test drink. The food intake was recorded thereafter at an ad libitum lunch. Results: Microcapsular formulations targeting the distal small intestinal delivery of fat, but not carbohydrate or protein, markedly enhance PYY release relative to macronutrient delivery in gastric release formulations. Food intake at an ad libitum meal was lowest after consumption of the formulation releasing fat at the distal small intestine. Conclusion: Targeting of fat to the distal small intestine in delayed release microcapsules enhanced PYY release and was associated with reductions in food intake.

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