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Associations of cigarette smoking with disease phenotype and type I interferon expression in primary Sjogren's syndrome

Artikel i vetenskaplig tidskrift
Författare P. Olsson
I. L. A. Bodewes
A. M. Nilsson
C. Turesson
Lennart T. H. Jacobsson
E. Theander
M. A. Versnel
T. Mandl
Publicerad i Rheumatology International
Volym 39
Nummer/häfte 9
Sidor 1575-1584
ISSN 0172-8172
Publiceringsår 2019
Publicerad vid Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning
Sidor 1575-1584
Språk en
Länkar dx.doi.org/10.1007/s00296-019-04335...
Ämnesord Sjogren's syndrome, Cigarette smoking, Interferon type I, Autoimmune diseases, tobacco, prevalence, signatures, Rheumatology
Ämneskategorier Reumatologi och inflammation

Sammanfattning

Several studies have shown a negative association between smoking and primary Sjogren's syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patients filled out the EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI) form and a structured questionnaire regarding smoking habits. EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI) scores were calculated and blood samples were analysed for type I interferon signature using RT-PCR. Of 90 patients (93% women, median age 66.5 years), 72% were type I IFN signature positive and 6, 42 and 53% were current, former and never smokers, respectively. No significant differences by smoking status were found regarding ESSDAI total score, activity in the ESSDAI domains or type I IFN signature. Patients with a higher cumulative cigarette consumption (>= median) had higher scores in ESSPRI total [5.0 (3.0-6.3) vs 8.0 (6.0-8.3); p < 0.01] and ESSPRI sicca and pain domains. Comparing type I IFN signature negative and positive patients, the latter had significantly lower activity in ESSDAI articular domain (7/25 vs 3/64; p < 0.01) and lower scores in ESSPRI total [7.7 (5.2-8.2) vs 6.0 (4.0-7.7); p = 0.04]. Smoking was not associated with disease phenotype although patients with a higher cumulative cigarette consumption had worse symptoms in some disease domains. Current smokers were few making it difficult to draw any firm conclusions about associations to current smoking.

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