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Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease

Artikel i vetenskaplig tidskrift
Författare S. Fossati
J. Ramos Cejudo
L. Debure
E. Pirraglia
J. Y. Sone
Y. Li
J. Chen
T. Butler
Henrik Zetterberg
Kaj Blennow
M. J. de Leon
Publicerad i Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volym 11
Sidor 483-492
ISSN 2352-8729
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 483-492
Språk en
Länkar dx.doi.org/10.1016/j.dadm.2019.05.0...
Ämnesord Blood biomarkers, Cognition, CSF P-Tau, CSF tau, MRI, Plasma tau
Ämneskategorier Neurovetenskaper

Sammanfattning

Introduction: Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear. Methods: Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Results: Plasma tau was higher in patients with AD than cognitively normal controls (P <.001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Discussion: Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures. © 2019 The Authors

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