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Bile acid changes after metabolic surgery are linked to improvement in insulin sensitivity

Artikel i vetenskaplig tidskrift
Författare Sofie Ahlin
C. Cefalu
I. Bondia-Pons
E. Capristo
L. Marini
A. Gastaldelli
G. Mingrone
J. J. Nolan
Publicerad i British Journal of Surgery
Volym 106
Nummer/häfte 9
Sidor 1178-+
ISSN 0007-1323
Publiceringsår 2019
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 1178-+
Språk en
Länkar dx.doi.org/10.1002/bjs.11208
Ämnesord y gastric bypass, weight-loss, bariatric surgery, nuclear receptor, improved glucose, identification, resistance, increases, ligands, fxr, Surgery, fronzo ra, 1979, american journal of physiology, v237, pe214
Ämneskategorier Kirurgi

Sammanfattning

Background: Metabolic surgery is associated with a prompt improvement in insulin resistance, although the mechanism of action remains unknown. The literature on bile acid changes after metabolic surgery is conflicting, and insulin sensitivity is generally assessed by indirect methods. The aim of this study was to investigate the relationship between improvement in insulin sensitivity and concentration of circulating bile acids after biliopancreatic diversion (BPD) and Roux-en-Y gastric bypass (RYGB). Methods: This was a prospective observational study of nine patients who underwent BPD and six who had RYGB. Inclusion criteria for participation were a BMI in excess of 40 kg/m(2), no previous diagnosis of type 2 diabetes and willingness to participate. Exclusion criteria were major endocrine diseases, malignancies and liver cirrhosis. Follow-up visits were carried out after a mean(s.d.) of 185.3(72.9) days. Fasting plasma bile acids were assessed by ultra-high-performance liquid chromatography coupled with a triple quadrupole mass spectrometer, and insulin sensitivity was measured by means of a hyperinsulinaemic-euglycaemic clamp. Results: A significant increase in all bile acids, as well as an amelioration of insulin sensitivity, was observed after metabolic surgery. An increase in conjugated secondary bile acids was significantly associated with an increase in insulin sensitivity. Only the increase in glycodeoxycholic acid was significantly associated with an increase in insulin sensitivity in analysis of individual conjugated secondary bile acids. Conclusion: Glycodeoxycholic acid might drive the improved insulin sensitivity after metabolic surgery.

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