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Erlangen Score Predicts Cognitive and Neuroimaging Progression in Mild Cognitive Impairment Stage of Alzheimer's Disease

Artikel i vetenskaplig tidskrift
Författare Tobias Skillbäck
J. Kornhuber
Kaj Blennow
Henrik Zetterberg
P. Lewczuk
Publicerad i Journal of Alzheimers Disease
Volym 69
Nummer/häfte 2
Sidor 551-559
ISSN 1387-2877
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 551-559
Språk en
Länkar dx.doi.org/10.3233/jad-190067
Ämnesord A beta(1-42), Alzheimer's disease, biomarkers, cerebrospinal fluid, Erlangen score, P-tau, T-tau, cerebrospinal-fluid, validation, biomarkers, Neurosciences & Neurology
Ämneskategorier Neurovetenskaper

Sammanfattning

Background: To alleviate the interpretation of the core Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers, amyloid beta(1-42) (A beta(42)), total tau (T-tau), and phosphorylated tau (P-tau), the Erlangen Score (ES) interpretation algorithm has been proposed. Objective: In this study, we aim to assess the predictive properties of the ES algorithm on cognitive and neuroimaging outcomes in mild cognitive impairment (MCI). Methods: All MCI subjects with an available baseline CSF sample from ADNI-1 were included (n = 193), and assigned an ES between 0 and 4 based on their baseline CSF biomarker profile. Structural magnetic resonance imaging brain scans and MMSE and ADAS-Cog scores were collected at up to 7 times in follow-up examinations. Results: We observed strong and significant correlations between the ES at baseline and neuroimaging and cognitive results with patients with neurochemically probable AD (ES = 4) progressing significantly (p <= 0.01) faster than those with a neurochemically improbable AD (ES = 0 or 1), and the subjects with neurochemically possible AD (ES = 2 or 3) in-between these two groups. Conclusion: This study further demonstrates the utility of the ES algorithm as a as a tool in predicting cognitive and imaging progression in MCI patients.

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