Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Serum miR-30c-5p is a pot… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Serum miR-30c-5p is a potential biomarker for multiple system atrophy

Artikel i vetenskaplig tidskrift
Författare A. Vallelunga
T. Iannitti
G. Dati
S. Capece
Maugeri Marco
E. Tocci
M. Picillo
G. Volpe
A. Cozzolino
M. Squillante
G. Cicarelli
P. Barone
M. T. Pellecchia
Publicerad i Molecular Biology Reports
Volym 46
Nummer/häfte 2
Sidor 1661-1666
ISSN 0301-4851
Publiceringsår 2019
Publicerad vid Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning
Sidor 1661-1666
Språk en
Länkar dx.doi.org/10.1007/s11033-019-04614...
Ämnesord Parkinson's disease, MiRNAs, Multiple system atrophy, MiR-30c-5p, Biomarker, Synucleinopathies, autophagy, accumulation, expression, micrornas, disease, models, plasma, Biochemistry & Molecular Biology
Ämneskategorier Biokemi och molekylärbiologi

Sammanfattning

Multiple system atrophy (MSA) is a neurodegenerative disease that belongs to the synucleinopathies. Clinically, there is an overlap between MSA and Parkinson's disease (PD), especially at the early disease stage. However, these two pathologies differ in terms of disease progression. Currently, no biomarker exists to differentiate MSA from PD. MicroRNAs are non-coding RNAs implicated in gene expression regulation. MiRNAs modulate cellular activity and they control a range of physiological and pathological functions. miRNAs are found in biofluids, such as blood, serum, plasma, saliva, and cerebrospinal fluid. Many groups, including ours, found that circulating miRNAs are differently expressed in blood, plasma, serum and cerebrospinal fluid of PD and MSA patients. In the present study, our primary aim was to determine if serum mir-30-5p and mir-148b-5p can be used as biomarkers for early diagnosis of PD and/or MSA. Our secondary goal was to determine if serum levels of those miRNAs can be correlated with the patients' clinical profile. Using quantitative PCR (qPCR), we evaluated expression levels of miR-30c-5p and miR148b-5p in serum samples from PD (n=56), MSA (n=49), and healthy control (n=50) subjects. We have found that miR-30c-5p is significantly upregulated in MSA if compared with PD and healthy control subjects. Moreover, serum miR-30c-5p levels correlate with disease duration in both MSA and PD. No significant difference was found in miR-148b-5p among MSA, PD and healthy control subjects. Our results suggest a possible role of serum miR-30-5p as a biomarker for diagnosis and progression of MSA.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?