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Mycophenolate mofetil ameliorates perivascular T lymphocyte inflammation and reduces the double-negative T cell population in SLE-prone MRLlpr/lpr mice.

Artikel i vetenskaplig tidskrift
Författare C A Jonsson
M Erlandsson
L Svensson
Johan Mölne
H Carlsten
Publicerad i Cellular immunology
Volym 197
Nummer/häfte 2
Sidor 136-44
ISSN 0008-8749
Publiceringsår 1999
Publicerad vid Institutionen för laboratoriemedicin , Avdelningen för patologi
Sidor 136-44
Språk en
Länkar dx.doi.org/10.1006/cimm.1999.1570
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Anti-Inflammatory Agents, Non-Steroidal, pharmacology, B-Lymphocytes, drug effects, immunology, Cell Count, Cell Division, Concanavalin A, pharmacology, Cyclophosphamide, pharmacology, Cytokines, blood, genetics, Disease Models, Animal, Female, Hypersensitivity, Delayed, Immunophenotyping, Immunosuppressive Agents, pharmacology, Kidney, blood supply, cytology, immunology, Lupus Erythematosus, Systemic, immunology, Male, Mice, Mice, Inbred MRL lpr, Mycophenolic Acid, analogs & derivatives, pharmacology, RNA, Messenger, Salivary Glands, blood supply, cytology, Spleen, cytology, immunology, T-Lymphocytes, cytology, drug effects, immunology, Vasculitis, pathology
Ämneskategorier Reumatologi och inflammation

Sammanfattning

Effects on T lymphocyte mediated pathology, phenotypes, and functions in MRLlpr/lpr mice given mycophenolate mofetil (MMF) (100 mg/kg/day) via drinking water or controls given ip cyclophosphamide (CYC) injections (1.8 mg/mouse/week) or water were described. Both MMF and CYC treatment diminished kidney and large salivary gland perivascular cell infiltrates, reduced profoundly double-negative (DN) T cell frequencies, decreased total lymphocyte number in spleen, and increased in vitro proliferative response to Con A. IFN-gamma and IL-10 in supernatants from Con A stimulated spleen cells were augmented after MMF but not CYC treatment. MMF treatment increased whereas CYC reduced IL-12 in serum. Kidney expressions of IFN-gamma, IL-10, and IL-12 mRNA were unaffected by MMF but decreased by CYC. Our results demonstrate that MMF and CYC suppress perivascular T lymphocyte inflammation by reducing the DN T cell population and by amelioration of T cell function. The varying cytokine patterns suggest different mechanisms of the two drugs.

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