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The prevalence of prolonged QTc increases by GOLD stage, and is associated with worse survival among subjects with COPD

Artikel i vetenskaplig tidskrift
Författare U. Nilsson
I. Kanerud
U. B. Diamant
A. Blomberg
Berne Eriksson
A. Lindberg
Publicerad i Heart & Lung
Volym 48
Nummer/häfte 2
Sidor 148-154
ISSN 0147-9563
Publiceringsår 2019
Publicerad vid Krefting Research Centre
Sidor 148-154
Språk en
Länkar dx.doi.org/10.1016/j.hrtlng.2018.09...
Ämnesord Epidemiology, Comorbidity, Cardiology, Electrocardiogram, Pulmonary disease, Chronic obstructive, obstructive lung-disease, sudden cardiac death, risk-factors, pulmonary-disease, interval, mortality, duration, electrocardiography, recommendations, underdiagnosis, Cardiovascular System & Cardiology, Nursing, Respiratory System, ewart ag, 1995, respiratory medicine, v89, p79
Ämneskategorier Lungmedicin och allergi, Kardiologi

Sammanfattning

Background: The role of QTc-prolongation, in relation to the increased mortality in COPD, is unclear. Objectives: To estimate the prevalence and prognostic impact, assessed as mortality, of QTc-prolongation in COPD, restrictive spirometric pattern (RSP), and normal lung function (NLF), respectively. Methods: All individuals (n = 993) with COPD and age- and sex-matched non-obstructive referents were identified from well-defined population-based cohorts examined in Northern Sweden in 2002-04. In 2005, the study-sample was invited to re-examination including ECG; QTc was calculated and mortality data collected until 31st December 2010. Results: The prevalence of QTc-prolongation was higher among people with RSP than among those with NLF and, although similar in NLF and COPD, the prevalence increased by COPD-severity. Among participants with COPD, those with QTc prolongation had higher mortality than those with normal QTc, while no such differences were found among participants with NLF or RSP. Conclusion: Among participants with COPD, the prevalence of QTc-prolongation increased by disease-severity and was associated with mortality. (C) 2018 Elsevier Inc. All rights reserved.

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