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Future Liver Remnant (FLR) Increase in Patients with Colorectal Liver Metastases Is Highest the First Week After Portal Vein Occlusion: FLR Increase in Patients with CRLM Is Highest the First Week After PVO

Artikel i vetenskaplig tidskrift
Författare K. Hasselgren
P. Sandstrom
B. I. Rosok
E. Sparrelid
G. Lindell
P. N. Larsen
A. L. Larsson
N. A. Schultz
B. A. Bjornbeth
B. Isaksson
M. Rizell
B. Bjornsson
Publicerad i Journal of Gastrointestinal Surgery
Volym 23
Nummer/häfte 3
Sidor 556-562
ISSN 1091-255X
Publiceringsår 2019
Publicerad vid Institutionen för medicin
Sidor 556-562
Språk en
Länkar dx.doi.org/10.1007/s11605-018-4031-...
Ämnesord Colorectal liver metastases, Liver surgery, Future liver remnant, Portal vein embolization, Portal vein ligation, 2-stage hepatectomy, staged hepatectomy, major hepatectomy, tumor-growth, segment-iv, embolization, volume, chemotherapy, hypertrophy, ligation, Gastroenterology & Hepatology, Surgery
Ämneskategorier Kirurgi

Sammanfattning

BackgroundPortal vein occlusion (PVO) is an established method to increase the volume of the future liver remnant (FLR). The main reasons for not proceeding to radical hepatectomy are lack of volume increase and tumor progression due to a wait-time interval of up to 8weeks. The hypothesis was that the increase in FLR volume is not linear and is largest during the first weeks.MethodsPatients with colorectal liver metastases (CRLM) and standardized future liver remnant (sFLR) <30% treated with PVO were prospectively included. All patients had at least one CT evaluation before radical hepatectomy.ResultsForty-eight patients were included. During the first week after PVO, the kinetic growth rate (KGR) was 5.4 (4), compared to 1.5 (+/- 2) between the first and second CT (p<0.05). For patients reaching adequate FLR and therefore treated with radical hepatectomy, the KGR was 7 (+/- 4) the first week, compared to 4.3 (+/- 2) for patients who failed to reach a sufficient volume (p=0.4). During the interval between the first and second CT, the KGR was 2.2 (+/- 2), respectively (+/- 0.1) (p=0.017).Discussion p id=Par4 The increase in liver volume after PVO is largest during the first week. As KGR decreases over time, it is important to shorten the interval between PVO and the first volume evaluation; this may aid in decision-making and reduce unnecessary waiting time.

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