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Higher menopausal age but no differences in parity in women with polycystic ovary syndrome compared with controls.

Artikel i vetenskaplig tidskrift
Författare Maria Forslund
Kerstin Landin-Wilhelmsen
Johanna Schmidt
Mats Brännström
Penelope Trimpou
Eva Dahlgren
Publicerad i Acta obstetricia et gynecologica Scandinavica
Volym 98
Nummer/häfte 3
Sidor 320-326
ISSN 1600-0412
Publiceringsår 2019
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
Sidor 320-326
Språk en
Länkar dx.doi.org/10.1111/aogs.13489
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Endokrinologi, Obstetrik och gynekologi, Reproduktiv hälsa

Sammanfattning

To address the question of whether women with polycystic ovary syndrome (PCOS) reach menopause later than age-matched controls, we conducted a follow-up cohort study of women with well-characterized PCOS that was diagnosed 24 years ago. The hypothesis was that women with PCOS would reach menopause later than non-PCOS women. Parity during these 24 years was also studied.Twenty-seven women diagnosed with PCOS in 1992 (mean age 29.5 years) were re-examined in 2016 (mean age 52.4 years). Randomly selected women, n = 94 (mean age 52.4 years), from the same geographic area included in the World Health Organization MONICA study, Gothenburg, Sweden, served as controls.The mean menopausal age in women with PCOS was higher than in controls (53.3 ± 2.2 years vs 49.3 ± 3.5 years, P < 0.01). Serum-follicle stimulating hormone levels were lower in the PCOS women than in controls (31.0 ± 28.1 IU/L vs 52.3 ± 37.7 IU/L, P = 0.01). There was no difference in parity between women with PCOS (1.9 ± 1.3 children, range 0-4) and controls (1.7 ± 1.0, range 0-4 children).Women with PCOS reached menopause 4 years later and had lower serum-follicle stimulating hormone compared with age-matched controls. Neither parity nor nulliparity differed between women with PCOS and controls.

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